高原低氧影响心血管药物体内代谢的研究进展  

Research Advances on the Impact of High-altitude Hypoxia on Cardiovascular Drug Metabolism

作　　者：王梦悦 李向阳[1] WANG Mengyue;LI Xiangyang(College of Pharmacy,Qinghai University,Xining 810100,China)

机构地区：[1]青海大学药学院,西宁810100

出　　处：《医药导报》2024年第6期935-940,共6页Herald of Medicine

基　　金：高原低氧环境药物代谢研究科研基础条件平台(2021-ZJ-T03)。

摘　　要：高原低氧环境显著影响机体心血管系统,使体内药物代谢受到一定影响。药物的药动学参数、药物代谢酶活性和药物转运体的活性及表达均会发生改变。该文系统回顾高原低氧对心血管系统药物代谢的研究进展,探讨高原低氧条件下药动学、药物代谢酶和药物转运体的变化,以期为高原低氧环境下药物代谢的研究提供参考。Hypoxic environment at high-altitude significantly affects the cardiovascular system to a certain extent,leading to alterations in drug metabolism in vivo.Pharmacokinetic parameters,expression and function of drug metabolism enzymes and transporters can all be affected.This paper systematically reviews the research progress on the effects of high-altitude hypoxia on the cardiovascular drugs metabolism,discusses changes in pharmacokinetics,drug metabolism enzymes and transporters under high-altitude hypoxia conditions,aiming to provide relevant theoretical support for the study of drug metabolism under high altitude hypoxia conditions.

关 键 词：高原低氧 药动学 药物代谢酶 药物转运体 

分 类 号：R28[医药卫生—中药学] R743.9[医药卫生—中医学]