基于数据挖掘的中医药治疗雄激素性脱发用药规律研究  

Study on Medication Rule of Traditional Chinese Medicine for Androgenetic Alopecia Based on Data Mining

作　　者：曲梦柔 高冬梅 牟翔宇 曲嵩霖 薛玲[3] 张守亮 郭英慧 QU Mengrou;GAO Dongmei;MOU Xiangyu;QU Songlin;XUE Ling;ZHANG Shouliang;GUO Yinghui(College of Traditional Chinese Medicine,Shandong University of Traditional Chinese Medicine,Ji′nan 250355,China;Emotion Medicine,The Key Discipline of State Administration of Traditional Chinese Medicine,Ji′nan 250355,China;College of Pharmacy,Shandong University of Traditional Chinese Medicine,Ji′nan 250355,China;Ji′nan Qingzhenmei Technology Co.LTD,Ji′nan 250300,China)

机构地区：[1]山东中医药大学中医学院,济南250355 [2]国家中医药管理局中医药重点学科中医情志学学科,济南250355 [3]山东中医药大学药学院,济南250355 [4]济南情珍美科技有限公司,济南250300

出　　处：《世界中医药》2024年第6期856-863,870,共9页World Chinese Medicine

基　　金：国家自然科学基金面上项目(82074293);山东省中医药联合基金重点支持项目(ZR2021LZY043)。

摘　　要：目的:对中药内外治疗雄激素性脱发(AGA)的方剂用药规律进行统计分析,为临床治疗AGA提供理论依据。方法:检索国家知识基础设施数据库(CNKI)、中国生物医学文献数据库(CBM)、中国学术期刊数据库(CSPD)及中文科技期刊数据库(CCD),收集自建库至2022年2月18日与AGA有关的中医药文献,运用IBM SPSS Modeler、IBM SPSS Statistics 26.0等软件对中药数据进行关联规则、系统聚类及用药规律分析。结果:共筛选出183篇文献,获得内服方药178首,外用方药56首,内服单味药188味,外用单味药124味。内服单味药应用频次前3位分别为何首乌、茯苓、丹参,性味归经统计分析多性寒、味甘、归肝经,功效分析多为补益药,关联规则分析常用药对为墨旱莲+女贞子,聚类分析共得出4个内服核心方药。外用单味药应用频次前3位分别为何首乌、侧柏叶、苦参,性味归经统计分析多性温、味苦、归肝经,功效分析多为清热药,关联规则分析常用药对为墨旱莲+女贞子,聚类分析共得出2个外用核心处方。结论:治疗AGA内服中药多以补益药、利水渗湿药为主,性味多以甘寒为主,归经以肝脾为主;外用中药多以清热药、解表药为主,性味多以苦温为主,归经以肝肺为主,为临床提供参考。Objective:Statistical analysis was conducted on prescription medication rules of internal and external treatment of androgenetic alopecia(AGA),providing theoretical basis for clinical treatment of AGA.Methods:The Chinese medicine literature related to AGA until February 18,2022 was retrieved from China National Knowledge Infrastructure(CNKI),China Biology Medicine(CBM)Database,Chinese Science Periodical Database(CSPD)and Chinese Citation Database(CCD)by computer.IBM SPSS Modeler,IBM SPSS Statistics 26.0 and other software were used for association rules,systematic clustering and medication rules of TCM data.Results:A total of 183 literatures were screened,including 178 prescriptions for internal use,56 prescriptions for external use,comprising 188 types of single herb for internal use and 124 types of single herb for external use.The top three prescriptions of single herbs were Polygonum multiflorum,Poria cocos,and Salvia miltiorrhiza.Statistical analysis of property,taste and meridians showed that the majority were cold in nature,sweet in flavor and belonged to liver meridian.In efficacy analysis,most drugs were tonic drugs.Association rule analysis revealed common herb pairs were Yerbadetajo Herb and Fructus Ligustri Lucidi,and clustering analysis yielded four core internal medicine prescriptions.The top three frequently used single external use drugs were Polygonum multiflorum,Platycladus orientalis and Sophora flavescens.Statistical analysis of property,taste and meridians showed that the majoritywere warm in nature,bitter in taste and belonged to the liver meridian.In efficacy analysis,most drugs were heat-relieving drugs.Association rule analysis revealed that common herb pairs were Yerbadetajo Herb and Fructus Ligustri Lucidi.Clustering analysis yielded two core external medicine prescriptions.Conclusion:In the treatment of AGA,the traditional Chinese medicines are mainly tonifying drugs and invigorating drugs,with properties mainly sweet and cold,and belonging to the liver and spleen meridians.The externa

关 键 词：雄激素性脱发 用药规律 数据挖掘 关联规则 系统聚类 频次分析 内服 外用 

分 类 号：R283[医药卫生—中药学]