通络活血虫类中药在抗恶性肿瘤血管生成中的研究现状  

Research Status of the Worm Drugs of Dredging Collaterals and Activating Blood in the Anti-angiogenesis of Malignant Tumors

作　　者：蒋伶俐 毛启远 李道睿[1] JIANG Lingli;MAO Qiyuan;LI Daorui(Guang′anmen Hospital,China Academy of Chinese Medical Sciences,Beijing 100053,China)

机构地区：[1]中国中医科学院广安门医院,北京100053

出　　处：《世界中医药》2024年第6期910-915,共6页World Chinese Medicine

基　　金：国家自然科学基金面上项目(82074405)。

摘　　要：血管生成在恶性肿瘤细胞的增殖和侵袭转移中具有重要作用,抗血管生成药物在恶性肿瘤内科治疗中已取得一定疗效。中医药在肿瘤治疗方面具有多成分、多靶点、多环节且不良反应小的优势,用络病理论阐释肿瘤血管生成病机乃是近年来中医药的研究热点之一。基于络病理论“通络”治则提出的“通络活血”治法在临床中被广泛应用,且通络活血虫类药物也是经方中较为峻猛、能除疴疾的重要中药。Angiogenesis plays an important role in the proliferation,invasion and metastasis of malignant tumor cells.Anti-angiogenesis drugs have been effective in the medical treatment of malignant tumors.Traditional Chinese medicine(TCM)has the advantages of multi-component,multi-target,multi-link and small adverse reactions in the treatment of tumor.Explaining the pathogenesis of tumor angiogenesis with the theory of collateral disease has become one of the research hotspots in TCM in recent years.The treatment of“dredging collaterals and activating blood”,based on the theory of“TongLuo”,has been widely used in clinical practice,and the drugs of which are also important Chinese medicines in the meridian formulas,which are more severe and more important in removing diseases.The article outlines the relationship between the theory of collateral disease and tumor angiogenesis and the therapeutic effects of the drugs of dredging collaterals and activating blood worm chinese materia medica in malignant tumors,demonstrates the anti-angiogenic mechanism of the commonly used drugs and classic formulas of dredging collaterals and activating blood worm chinese materia medica in tumors,and puts forward the strengths and deficiencies in the theoretical and experimental study of anti-tumor angiogenesis,so as to provide references for the follow-up further research.

关 键 词：通络活血 虫类药 抗血管生成药物 恶性肿瘤 研究现状 

分 类 号：R285[医药卫生—中药学]