Clinical pharmaceutical analysis of combined therapy with amlodipine benzenesulfonate and atorvastatin calcium for elderly patients with hypertension and dyslipidemia  

作　　者：陈立新 CHEN Li-xin(Outpatient Western Pharmacy at Yanshou Hospitaltumor hospitalthe affiliated Hospital(Group)of Putian University Medical Group,Putian city 351100,Fujian province,China)

机构地区：[1]Outpatient Western Pharmacy at Yanshou Hospital,tumor hospital,the affiliated Hospital(Group)of Putian University Medical Group,Putian city 351100,Fujian province,China

出　　处：《South China Journal of Cardiology》2024年第1期38-43,共6页岭南心血管病杂志（英文版）

摘　　要：Background Hypertension combined with dyslipidemia is the main cause of cerebrovascular and cardiovascular accidents in elderly patients,and actively controlling blood pressure and lipid levels is the best way to reduce the risk of cardiovascular accidents and death.This study focused on the clinical pharmaceutical analysis of combined therapy with amlodipine benzenesulfonate and atorvastatin calcium for elderly patients with hypertension and dyslipidemia.Methods A total of 292 elderly patients with hypertension and dyslipidemia from August 2022 to February 2023 were selected and grouped according to random number table method,and evenly assigned to control group(n=146)and observation group(n=146).Control group was treated with amlodipine besylate,and observation group was treated with combined therapy with amlodipine benzenesulfonate and atorvastatin calcium.The effects and adverse reactions of the two groups were compared,and the changes of blood pressure and lipid indexes before and after treatment were also compared.Results The total effective rate of observation group was higher than that of control group,the difference was significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).No significant differences were found in systolic blood pressure,diastolic blood pressure,total cholesterol and triglyceride between the two groups before treatment(P>0.05).While after treatment,the level of systolic blood pressure,diastolic blood pressure,total cholesterol and triglyceride in the observation group were lower than those in the control group(P<0.05).Conclusions The combination therapy with amlodipine benzenesulfonate and atorvastatin calcium is effective and safe,improving blood pressure and lipid levels in patients with hypertension and dyslipidemia,and can be widely applied to elderly patients with hypertension and dyslipidemia.[S Chin J Cardiol 2024;25(1):38-43].

关 键 词：Amlodipine benzenesulfonate Atorvastatin calcium Hypertension combined with dyslipidemia 

分 类 号：R544.1[医药卫生—心血管疾病] R589.2[医药卫生—内科学]