抗片形吸虫病疫苗的研究进展  

Research progress on vaccines against fascioliasis

作　　者：李慈怀(综述) 陈凤 孙强明(审校)[3] LI Cihuai;CHEN Feng;SUN Qiangming(School of Public Health,Dali University,Dali 671000,Yunnan Province,China;不详)

机构地区：[1]大理大学公共卫生学院,云南大理671000 [2]云南省大理白族自治州血吸虫病防治研究所,云南大理671000 [3]中国医学科学院,北京协和医学院,医学生物学研究所,云南省重大传染病疫苗研发重点实验室,云南昆明650118

出　　处：《中国生物制品学杂志》2024年第4期497-504,共8页Chinese Journal of Biologicals

基　　金：云南省高层次卫生健康技术人才培养专项经费资助(媒介生物控制学H-2018072);国家寄生虫资源库资助(NPRC-2019-194-30)。

摘　　要：片形吸虫病是由片形吸虫感染引起的人畜共患病,该病会引发机体的急慢性损伤,严重危害畜牧业发展,造成极大经济损失,目前用于治疗片形吸虫病的药物单一,且有耐药性产生,因此,急需更经济、可行的方式对家畜片形吸虫进行防治,以减少或避免人畜患病。疫苗是一种经济、有效的预防病原体感染的手段,有可能在片形吸虫病的预防中起到重要作用。本文就片形吸虫的抗原免疫应答机制及其疫苗研发现状作一综述,以期为片形吸虫病的防治提供科学参考和理论依据。Fascioliasis is a zoonotic disease caused by fasciola infection,which will cause acute and chronic damage to the body,seriously endanger the development of animal husbandry,and cause great economic losses.At present,the drugs used to treat fascioliasis are single with drug resistance occurring.Therefore,there is an urgent need for a more economical and feasible way to control Fasciola in livestock to reduce or avoid diseases in humans and animals.Vaccine is an economical and effective means to prevent pathogen infection,which may play an important role in the prevention of fascioliasis.In this paper,the antigenic immune response mechanism of fasciola and its vaccine research are reviewed,so as to provide scientific reference and theoretical basis for the control of fascioliasis.

关 键 词：片形吸虫病 危害 疫苗 

分 类 号：R383.26[医药卫生—医学寄生虫学]