季铵化两亲碳渣外用抗菌凝胶剂的药效学评价  

Pharmacodynamic evaluations of quaternized amphiphilic carbonaceous particles topical antimicrobial gel

作　　者：李珊珊 王雪平 明白露 吴强[2] LI Shanshan;WANG Xueping;MING Bailu;WU Qiang(College of Medicine,Kaifeng University,Henan Kaifeng 475003,China;College of Pharmacy,Henan University,Henan Kaifeng 475004,China;No.5 Municipal Hospi tal,Medical imaging department Henan Kaifeng 475003,China)

机构地区：[1]开封大学医学部,河南开封475003 [2]河南大学药学院,河南开封475004 [3]开封市第五人民医院医学影像科,河南开封475003

出　　处：《中国医院药学杂志》2024年第7期752-756,852,共6页Chinese Journal of Hospital Pharmacy

基　　金：国家自然科学基金项目(编号:21471046)。

摘　　要：目的:对季铵化两亲碳渣外用抗菌凝胶剂(quaternized amphiphilic carbonaceous particles topical antimicrobial gel,TAG/QACPs)在抗皮肤破损领域的潜在应用进行相关药效学评价。方法:通过平板涂布法,考察TAG/QACPs对金黄色葡萄球菌、大肠杆菌、白色念珠菌的活性影响;建立小鼠伤口感染模型,考察TAG/QACPs对受损创面的影响;通过家兔皮肤刺激性试验、过敏性试验,考察TAG/QACPs的应用安全性。结果:QACPs添加量为0.3mg·g^(-1)时,TAG/QACPs对受试菌的杀菌率可达99.9%;能够抑制小鼠伤口感染,14 d内使小鼠伤口愈合率达到98.86%;家兔完整皮肤未出现刺激反应和过敏反应。结论:TAG/QACPs是一种安全、有效、能够促进伤口愈合的新型外用抗菌制剂。OBJECTIVE To conduct pharmacodynamic evaluations of quaternized amphiphilic carbonaceous particles topical antimicrobial gel(TAG/QACPs)for its potential application for skin wound.METHODS The effects of TAG/QACPs on the activities of Staphylococcus aureus,Escherichia coli and Candida albicans were examined by spread plating.And the effects of TAG/QACPs on the wounds of the injured mice models were assessed.The safety of TAG/QACPs was analyzed by skin irritation and skin allergy tests in rabbits.RESULTS The bactericidal rate of TAG/QACPs for the tested microorganism was 99.9%at an addition volume of 0.3 mg·g^(-1)QACPs.Wound healing rate of injured mice models within 14 days was 98.86%after using this agent.No irritation or allergic reaction occurred after plating this agent onto the skin of rabbits.CONCLUSION TAG/QACPs is a safe and effective antibacterial agent capable of promoting skin wound healing.

关 键 词：两亲碳渣 季铵化 皮肤伤口感染 凝胶剂 药效学评价 

分 类 号：R944[医药卫生—药剂学]