天麻钩藤饮治疗神经系统疾病研究进展  

Treatment of Neurological Diseases with Tianma Goutengyin: A Review

作　　者：段建平 张杰[1] 王旭[1,2] 宋晓雨 李思敏 段平平 DUAN Jianping;ZHANG Jie;WANG Xu;SONG Xiaoyu;LI Simin;DUAN Pingping(The First Affiliated Hospital of Henan University of Chinese Medicine,Encephalopathy Center,Zhengzhou 450000,China;Henan University of Chinese Medicine,Zhengzhou 450046,China;Zhongmu County Hospital of Chinese Medicine,Zhengzhou 451450,China)

机构地区：[1]河南中医药大学第一附属医院,脑病中心,郑州450000 [2]河南中医药大学,郑州450046 [3]中牟县中医院,郑州451450

出　　处：《中国实验方剂学杂志》2024年第11期255-264,共10页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：河南省中医药科学研究专项基金项目(2022JDZX004);国家自然科学基金项目(81904264);全国中医临床特色技术传承骨干人才项目(国中医药人教函[2019]36号)。

摘　　要：神经系统疾病为临床常见病、多发病,是严重影响患者生活质量和身心健康的主要原因。天麻钩藤饮出自名医胡光慈编著的《中医内科杂病证治新义》,临床应用广泛,有平肝熄风、清热活血、安神、补益肝肾之功效。临床研究证实,天麻钩藤饮加减用药,或与针灸、西药合并应用治疗痴呆、头痛、眩晕病、高血压病、失眠症、帕金森病、卒中、癫痫等神经系统常见疾病,疗效显著,不良反应小,安全性高。基础研究发现,天麻钩藤饮整方与组方中单味药物主要活性成分如天麻素、天麻多糖、对羟基苯甲醇、钩藤碱、黄芩素、益母草碱、水苏碱、栀子苷、2,3,5,4,-四羟基二苯乙烯-2-Ο-β-D-葡萄糖苷、松脂醇二葡萄糖苷、茯苓酸、β-蜕皮甾酮、广寄生苷等可通过多靶点多途径,发挥抑制铁死亡、抗凋亡、抗氧化、调节神经递质、调节自噬、抗炎、减轻脑水肿、降脂、降压、改善血液循环等作用。该文通过对天麻钩藤饮治疗神经系统疾病的整方与单味药物作用机制、临床应用进行如下综述,以期为天麻钩藤饮的临床应用提供理论依据,并为该方后续的机制研究提供思路。Neurological diseases are common and frequent in clinical practices, which are the main reasons that affect the quality of life and physical and mental health of patients seriously. Tianma Goutengyin(TGY) is from the New Significance of Patterns and Treatment in Miscellaneous Diseases, which was compiled by a famous doctor, HU Guangci. TGY is widely used in clinical practice and has the effects of calming the liver and calming the wind, clearing heat and activating the blood, tranquilization, and nourishing the liver and kidneys. Clinical studies have confirmed that modified TGY can be used either alone or in combination with acupuncture or western medicine to treat dementia, headache, vertigo, hypertension, insomnia, Parkinson's disease, stroke, epilepsy, and other common neurological diseases, with significant curative effect, few side effects, and high safety. The main active constituents of single flavor drugs in the composition of TGY mainly include gastrodin, gastrodia elata blume polysaccharides, p-hydroxybenzyl alcohol, rhynchophylline, baicalein, leonurine, stachydrine, geniposide, 2,3,5,4,-tetrahydroxystilbene-2-Ο-β-D-glucoside, pinoresinol diglucoside, pachymic acid, β-ecdysteroid, avicularin, etc. It has been found that TGY and these constituents have the effects of ferroptosis inhibition, anti-apoptosis, anti-inflammation, and oxidation resistance, and they can regulate neurotransmitters and autophagy, reduce cerebral edema reduction, lower blood lipid and blood pressure, and improve blood circulation through multiple targets and pathways. This paper reviewed the clinical application of and the mechanism of the whole prescription and single flavor drugs of TGY in the treatment of neurological diseases, so as to provide a theoretical basis for the clinical application of TGY and offer ideas for the follow-up mechanism research of this prescription.

关 键 词：天麻钩藤饮 神经系统疾病 临床应用 药理机制 综述 

分 类 号：R284[医药卫生—中药学] R285[医药卫生—中医学] R289R287R22R2-031R33R24