多穗金粟兰中2个新环丁烷酰胺  

Two New Cyclobutane Alkaloids from Chloranthus multistachys

作　　者：朱成光 张卫青 刘培贵 梁伟[1] 张丽萍[1] 晏晨[1,2] ZHU Cheng-guang;ZHANG Wei-qing;LIU Pei-gui;LIANG Wei;ZHANG Li-ping;YAN Chen(Anshun City People′s Hospital,Anshun 561000,China;College of Pharmacy,Guizhou University of Traditional Chinese Medicine,Guiyang 550002,China)

机构地区：[1]安顺市人民医院,贵州安顺561000 [2]贵州中医药大学药学院,贵州贵阳550002

出　　处：《中药材》2023年第12期3000-3004,共5页Journal of Chinese Medicinal Materials

基　　金：贵州省卫生健康委科学技术基金项目(gzwkj2021-364,gzwkj2021-440);贵州省科技计划项2021目(黔科合支撑〔2022〕一般189);年度安顺市科技局社会发展项目(安市科社〔2021〕41号)。

摘　　要：目的:研究金粟兰科金粟兰属植物多穗金粟兰Chloranthus multistachys Pei的化学成分。方法:运用硅胶、Sephadex LH-20葡聚糖凝胶和半制备高效液相等现代色谱方法进行分离纯化,运用核磁共振波谱、质谱等波谱学技术结合理化性质鉴定化合物结构。对分离得到的新化合物进行体外细胞毒活性和抗艾滋病毒细胞株HIV-1的细胞活性的筛选。结果:从多穗金粟兰中分离纯化了4个化合物,分别鉴定为:pipercyclobutanamide A(1)、pipercyclobutanamide B(2)、(E)-N-phenethyl-3,4-methylenedioxyphenyl propenamide(3)、环银线草醇A(4)。结果:其中,化合物1和2为新化合物,化合物1和2对人乳腺癌细胞MDA-231具有较弱的抑制率。Objective:To study the chemical constituents of Chloranthus multistachys.Methods:The compounds were isolated and purified by modern chromatography methods,such as silica gel,Sephadex LH-20 and semi-prepared HPLC.The structures of the compounds were identified by nuclear magnetic resonance spectroscopy,mass spectrometry and other spectroscopic techniques combined with physical and chemical properties.The isolated compounds were screened for cytotoxic activity in vitro and for anti-HIV cell line HIV-1 in vitro.Results:Four compounds were isolated from Chloranthus multistachys and identified as pipercyclobutanamide A(1),pipercyclobutanamide B(2),(E)-N-phenethyl-3,4-methylenedioxyphenyl propenamide(3),cycloshizukaol A(4),respectively.Conclusion:Among them,compounds 1 and 2 are new compounds and have the weak inhibition rate on human breast cancer cell line MDA-231.

关 键 词：多穗金粟兰 Pipercyclobutanamide 化学成分 结构鉴定 

分 类 号：R284.1[医药卫生—中药学] R284.2[医药卫生—中医学] R285.5