支链氨基酸对严重腹部创伤患者血清蛋白和氮平衡水平的影响  

Effects of branched-chain amino acids on serum protein and nitrogen balance in patients with severe abdominal trauma

作　　者：毛丽 汤娜娜 邢继丹 MAO li;TANG Na-na;XING Ji-dan(Emergency Intensive Care Unit,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China)

机构地区：[1]郑州大学第一附属医院急诊重症监护病区,郑州450052

出　　处：《医药论坛杂志》2024年第6期649-652,共4页Journal of Medical Forum

摘　　要：目的探讨支链氨基酸对严重腹部创伤患者营养支持效果的影响,旨在提高严重腹部创伤患者的恢复效果。方法选取2021年1月至2022年12月于郑州大学第一附属医院接受治疗的94例严重腹部创伤患者,按照随机数表法将所有患者分为两组,对照组47例,给予复方氨基酸注射液(18AA-Ⅶ)治疗,观察组47例,接受复方氨基酸注射液(3AA)治疗,比较两组患者的血清蛋白水平、恢复氮平衡的时间以及不良反应的发生率。结果观察组治疗后白蛋白、前白蛋白、转铁蛋白水平分别是(42.19±2.44)g/L、(0.38±0.06)g/L和(2.54±0.30)g/L,均高于对照组(P<0.05),但观察组总蛋白水平[(63.28±4.76)g/L]与对照组[(62.73±3.96)g/L]比较差异无统计学意义(P>0.05);治疗前两组氮平衡水平比较无统计学意义(P>0.05),观察组治疗后累计氮平衡水平(-2.17±8.23)g/d,优于对照组的(-8.35±8.67)g/d,观察组氮平衡恢复时间(3.16±0.22)d,短于对照组的(5.33±0.36)d(P<0.05);观察组发生恶心呕吐2例,腹痛腹泻1例,术后切口感染0例,切口裂开1例,并发症发生率为8.51%,对照组发生恶心呕吐4例,腹痛腹泻4例,术后切口感染2例,切口裂开2例,并发症发生率为25.53%,组间对比差异显著(P<0.05)。结论支链氨基酸能够促进严重腹部创伤患者血清蛋白的合成,加快正氮平衡恢复速度,减少不良反应的发生率,临床上值得推广。Objective To explore the effect of branchchain amino acids on nutritional support in patients with severe abdominal trauma,in order to improve the recovery effect of patients with severe abdominal trauma.Methods Ninety-four patients with severe abdominal trauma who received treatment in our hospital from January 2021 to December 2022 were selected as the objects study.Two groups were divided into all patients according to the number random table.47 patients in the control group were treated compound amino acid injection(18AA-Ⅶ),and 47 patients in the observation group were treated with compound amino acid injection(3AA).Serum protein levels,time to restore nitrogen balance,and incidence of adverse reactions were compared between the two groups.Results Albumin the levels,transferrin and prealbumin in the group observation after treatment were(42.19±2.44)g/L,(0.38±0.06)g/L and(2.54±0.30)g/L,respectively,which were higher than those in the control group(P<0.05),There was no significant difference in total protein level between the observation group[(63.28±4.76)g/L]and the control group[(62.73±3.96)g/L](P>0.05).There was no statistical significance in nitrogen balance between the two groups before treatment(P>0.05).The cumulative nitrogen balance level of the observation group after treatment was(-2.17±8.23)g/d,which was better than that of the control group(-8.35±8.67)g/d,and the nitrogen balance recovery time of the observation group was(3.16±0.22)d.It was shorter than that of control group(5.33±0.36)d(P<0.05).In the observation group,there were 2 cases of nausea and vomiting,1 case of abdominal pain and diarrhea,0 cases of postoperative incision infection,1 case of incision dehiss,and the complication rate was 8.51%;In the control group,there were 4 cases of nausea and vomiting,4 cases of abdominal pain and diarrhea,2 cases of postoperative incision infection,2 cases of incision dehiss,and the complication rate was 25.53%,the difference between the two groups was significant(P<0.05).Conclusion Branched-

关 键 词：支链氨基酸 严重腹部创伤 血清蛋白 氮平衡 

分 类 号：R656[医药卫生—外科学]