清瘿解毒方联合针刺治疗亚急性甲状腺炎引发疼痛的临床观察  

Clinical Observation on the Treatment of Pain caused by Subacute Thyroiditis with Qingying Jiedu Decoction combined with Acupuncture

作　　者：杜亮亮 曾豆云 贺大智 戴北方 Du Liangliang;Zeng Douyun;He Dazhi;Dai Beifang(Yueyang Hospital of Traditional Chinese Medicine,Hunan,Yueyang 414000,China)

机构地区：[1]湖南省岳阳市中医医院,湖南岳阳414000

出　　处：《中国中医急症》2024年第5期835-838,共4页Journal of Emergency in Traditional Chinese Medicine

基　　金：湖南省卫生健康委科研立项课题(20201374)。

摘　　要：目的观察清瘿解毒方联合针刺治疗亚急性甲状腺炎引发疼痛的临床疗效。方法选择亚急性甲状腺炎疼痛患者84例,根据随机数字表法分为观察组与对照组各42例,对照组给予抗炎止痛常规治疗及针刺治疗,观察组在对照组基础上给予清瘿解毒方口服。观察两组治疗前后临床疗效、中医证候评分、血清疼痛因子[血清P物质(SP)、β-内啡肽(β-EP)、强啡肽(DYN)]水平、甲状腺功能指标[促甲状腺激素(TSH)、游离三碘甲状原氨酸(FT3)、游离甲状腺素(FT4)]、疼痛评分[视觉模拟疼痛评分(VAS),数字疼痛强度量表(NRS)]及安全性评价。结果治疗后观察组总有效率为92.86%,显著高于对照组的76.19%(P<0.05);两组中医证候评分、SP、β-EP、DYN水平及VAS、NRS评分均较治疗前降低,且观察组低于对照组(P<0.05);两组TSH水平显著高于治疗前,FT3、FT4水平显著低于治疗前,且观察组优于对照组(P<0.05)。两组治疗过程未出现不良事件。结论清瘿解毒方联合针刺治疗亚急性甲状腺炎引发疼痛临床疗效显著。Objective:To investigate the clinical effect of Qingying Jiedu Decoction combined with acupuncture in the treatment of pain caused by subacute thyroiditis.Methods:A total of 84 cases of subacute thyroiditis pain patients were divided into the observation group and the control group according to random number table method;the control group was given anti-inflammation and analgesic conventional treatment and acupuncture treatment,while the observation group was given Qingying Jiedu Decoction on the basis of the control group.The clinical effi⁃cacy,TCM syndrome score,serum pain factors[serum substance P(SP),β-endorphin(β-EP),strong enkephalin(DYN)]levels,thyroid function indicators[thyroid-stimulating hormone(TSH),free thyroxine3(FT3),free thyrox⁃ine4(FT4)],pain scores[visual analogue scale(VAS),numerical rating scale(NRS)]and safety evaluation before and after treatment were observed in the two groups.Results:After treatment,the total effective rate in the obser⁃vation group was 92.86%,which was higher than 76.19%in the control group(P<0.05).TCM syndrome score,se⁃rum pain factors and pain scores of the two groups were decreased after treatment(P<0.05).TSH levels of the two groups were significantly higher than before treatment,and FT3 and FT4 levels of the two groups were signifi⁃cantly lower than before treatment.All of the indicators in the observation group were better than those in the con⁃trol group(P<0.05).There were no adverse events during treatment in the two groups.Conclusion:Qingying Jie⁃du Decoction combined with acupuncture has significant clinical effect on pain caused by subacute thyroiditis.

关 键 词：亚急性甲状腺炎 清瘿解毒方 针刺 疼痛因子 疼痛评分 

分 类 号：R581[医药卫生—内分泌]