阿仑膦酸钠片辅助人工全髋关节置换治疗老年股骨颈骨折合并骨质疏松效果观察  

Observation on the effect of alendronate sodium tablets assisted total hip arthroplasty in the treatment of elderly femoral neck fractures with osteoporosis

作　　者：汤加柱 王波[1] Tang Jiazhu;Wang Bo(Department of Joint Surgery,Affiliated Hospital of Jiangsu University,Zhenjiang 212000,China)

机构地区：[1]江苏大学附属医院关节外科,江苏省镇江市212000

出　　处：《现代养生》2023年第20期1548-1551,共4页Health Protection and Promotion

摘　　要：目的 探讨阿仑膦酸钠片辅助人工全髋关节置换(THA)治疗老年股骨颈骨折合并骨质疏松的效果。方法 选取2020年5月-2021年12月医院收治的40例老年股骨颈骨折合并骨质疏松患者,根据组间性别、年龄、骨折部位、Garden分型等基线资料均衡可比的原则分为2组,对照组20例,观察组20例,所有患者知情并同意本次研究。对照组应用THA治疗,观察组在对照组基础上应用阿仑膦酸钠片辅助治疗,对比两组应用不同方法治疗后对骨代谢指标、骨密度、并发症及临床疗效的影响。结果 治疗前,两组患者骨钙素(BGP)、甲状旁腺素(PTH)、骨特异性碱性磷酸酶(BALP)水平比较,差异无统计学意义(P>0.05);治疗后,两组患者上述指标均改善,但观察组患者BGP和BALP水平高于对照组,PTH水平低于对照组,差异有统计学意义(P<0.05)。治疗前,两组患者腰椎、Wards三角区和股骨颈部位骨密度水平比较,差异无统计学意义(P>0.05);治疗后,两组患者上述指标均提高,但观察组患者各项骨密度水平高于对照组,差异有统计学意义(P<0.05)。观察组患者并发症发生率低于对照组,治疗优良率高于对照组,但组间差异均无统计学意义(P>0.05)。结论 在老年股骨颈骨折合并骨质疏松的治疗中,应用阿仑膦酸钠片辅助THA治疗取得理想效果,可有效改善骨代谢指标,提高骨密度。Objective To investigate the effect of alendronate sodium tablets assisted total hip arthroplasty(THA)in the treatment of elderly femoral neck fractures with osteoporosis.Methods Forty elderly patients with femoral neck fractures and osteoporosis admitted to the hospital from May 2020 to December 2021 were selected and divided into two groups based on the principle of balanced and comparable baseline data such as gender,age,fracture site,and Garden classification.The control group consisted of 20 patients and the observation group consisted of 20 patients.All patients were informed and agreed to this study.The control group received THA treatment,while the observation group received adjuvant treatment with alendronate sodium tablets on the basis of the control group.The effects of different treatment methods on bone metabolism indicators,bone density,complications,and clinical efficacy were compared between the two groups.Results Before treatment,there was no statistically significant difference in the levels of BGP,PTH,and BALP between the two groups of patients(P>0.05).After treatment,the above indicators improved in both groups of patients,but the BGP and BALP levels in the observation group were higher than those in the control group,while the PTH levels were lower than those in the control group,with a statistically significant difference(P<0.05).Before treatment,there was no statistically significant difference in bone density levels between the two groups of patients in the lumbar spine,Wards triangle,and femoral neck regions(P>0.05).After treatment,both groups of patients showed an increase in the above indicators,but the observation group had higher bone density levels than the control group,with a statistically significant difference(P<0.05).The incidence of complications in the observation group was lower than that in the control group,and the rate of excellent and good treatment was higher than that in the control group.However,there was no statistically significant difference between the groups(P>0.0

关 键 词：阿仑膦酸钠片 人工全髋关节置换 老年 股骨颈骨折 骨质疏松 临床疗效 

分 类 号：R687.3[医药卫生—骨科学]