妊娠各期甲状腺功能及hCG、雌孕激素水平的对比分析  

Comparative analysis of thyroid function,hCG,estrogen and progesterone levels in each stage of pregnancy

作　　者：李海朋[1] 董亚男[1] 闫丽纬 云丽媛 康欣[1] Li Haipeng;Dong Yanan;Yan Liwei;Yun Liyuan;Kang Xin(Tangshan Union Medical College Hospital,Tangshan 063000,China)

机构地区：[1]河北省唐山市协和医院,063000

出　　处：《现代养生》2023年第13期976-978,共3页Health Protection and Promotion

基　　金：河北省医学科学研究课题计划(编号:20160880)。

摘　　要：目的对比分析妊娠早、中、晚期孕妇甲状腺功能及hCG、雌孕激素水平。方法选取2019年6月-2022年6月来院进行常规孕前检查的90例妊娠期孕妇作为研究对象,按照妊娠时期的不同,分为妊娠早期、中期和晚期三组,每组30人。分别检测三组孕妇的促性腺激素(hCG)、促甲状腺激素(TSH)、孕酮(PROG)、雌二醇(E_(2))、游离雌三醇(uE_(3))和甲胎蛋白(AFP)。结果妊娠早、中、晚期孕妇hCG和TSH比较,差异均有统计学意义(P<0.05),其中hCG随妊娠期逐渐降低,而TSH逐渐升高。三组孕妇甲状腺功能紊乱发生率比较,差异无统计学意义(P>0.05)。三组孕妇PROG、E_(2)、uE_(3)和AFP水平均随妊娠期呈现上升趋势,组间比较差异均有统计学意义(P<0.05)。结论妊娠晚期,孕妇hCG水平降低,TSH水平升高,孕妇血清中PROG、E_(2)、uE_(3)和AFP也呈现上升趋势。Objective To compare the thyroid function,hCG,estrogen and progesterone levels in early,middle and third trimesters.Methods A total of 90 pregnant women in hospital from June 2019 to June 2022 were selected for routine pre pregnancy examination.According to the different pregnancy periods,they were divided into three groups:early pregnancy,mid pregnancy and late pregnancy,30 in each group.Gonadotropin were detected in three groups of pregnant women(hCG),thyroid stimulating hormone(TSH)and progesterone(PROG),estradiol(E_(2)),free three female alcohol(uE_(3))and alpha fetoprotein(AFP).Results The differences in hCG and TSH among pregnant women in the early,middle,and late stages of pregnancy were statistically significant(P<0.05),hCG gradually decreases during pregnancy,while TSH gradually increases.There was no statistically significant difference in the incidence of thyroid dysfunction among the three groups of pregnant women(P>0.05).The levels of PROG,E_(2),uE_(3),and AFP in the three groups of pregnant women showed an upward trend with pregnancy,and the differences between the groups were statistically significant(P<0.05).Conclusion In late pregnancy,hCG levels decrease while TSH levels increase,and the serum levels of PROG,E_(2),uE_(3),and AFP also show an upward trend.

关 键 词：妊娠期 甲状腺功能 促性腺激素 促甲状腺激素 雌孕激素 

分 类 号：R714.14[医药卫生—妇产科学]