从昼夜节律调控角度看创面愈合  

Exploring wound healing from the perspective of circadian rhythm regulation

作　　者：王达利 祁放 Wang Dali;Qi Fang(Department of Burns and Plastic Surgery,Affiliated Hospital of Zunyi Medical University,Zunyi 563003,China)

机构地区：[1]遵义医科大学附属医院烧伤整形外科,遵义563003

出　　处：《中华烧伤与创面修复杂志》2024年第5期401-406,共6页Chinese Journal of Burns And Wounds

基　　金：国家自然科学基金地区科学基金项目(82160379);国家自然科学基金面上项目(82072195);省部共建协同创新中心项目(教科技厅函〔2020〕39号);贵州省科技计划(黔科合支撑[2020]4Y148号)。

摘　　要：创面愈合是一个涉及多种细胞类型,如免疫细胞、成纤维细胞、角质形成细胞、血管内皮细胞和干细胞的复杂且精细调控的生物学过程。近年来,科学研究揭示了昼夜节律在调控创面愈合过程中的重要作用。尽管目前对于昼夜节律如何精确调控创面愈合的分子机制还不完全清楚,但不断积累的证据已经揭示,一些关键信号和细胞功能在昼夜节律调控创面愈合中扮演着重要角色。深入理解这些机制不仅对于揭示创面愈合的基本生物学过程有重要意义,而且有助于开发新的治疗策略,如通过调整昼夜节律来指导用药、优化创伤治疗。该文通过探讨当前有关昼夜节律调控创面愈合的研究成果,以期为这一新兴领域提供一个全面的视角,并为未来的研究方向提供有价值的见解。Wound healing is a complex and finely regulated biological process involving a variety of cell types,such as immune cells,fibroblasts,keratinocytes,endothelial cells,and stem cells.In recent years,scientific research has unveiled the significant role of circadian rhythms in the regulation of wound healing process.Although the molecular mechanisms by which circadian rhythms precisely regulate wound healing are not yet fully understood,accumulating evidence has revealed that some key signals and cellular functions play crucial roles in the circadian rhythm regulation of wound healing.A deeper understanding of these mechanisms is important not only to uncover the basic biological processes of wound healing,but also to develop new therapeutic strategies,such as regulating circadian rhythms to guide medication and optimize trauma treatment.By reviewing the current research results on circadian rhythm regulation of wound healing,this paper aims to provide a comprehensive perspective on this emerging field and provide valuable insights for future research directions.

关 键 词：昼夜节律 伤口愈合 时间疗法 分子过程 细胞信号 

分 类 号：R641[医药卫生—外科学]