脂肪因子在糖尿病外周血管病变中的作用研究进展  

Research advances on the role of adipokines in diabetic peripheral arterial diseases

作　　者：鲁珽[1] 刘啊敏 金启辉[2] 张玲 Lu Ting;Liu Amin;Jin Qihui;Zhang Ling(Center for Basic and Translational Research,the Second Affiliated Hospital of Zhejiang University School of Medicine,Hangzhou 310009,China;Department of Geriatric Medicine,the Second Affiliated Hospital of Zhejiang University School of Medicine,Hangzhou 310009,China;College of Life Science,Zhejiang Chinese Medical University,Hangzhou 310053,China)

机构地区：[1]浙江大学医学院附属第二医院基础和转化研究中心,杭州310009 [2]浙江大学医学院附属第二医院老年医学科,杭州310009 [3]浙江中医药大学生命科学学院,杭州310053

出　　处：《中华烧伤与创面修复杂志》2024年第5期495-500,共6页Chinese Journal of Burns And Wounds

基　　金：浙江省公益技术研究计划实验动物项目(GD21C040018)。

摘　　要：外周血管病变是糖尿病常见的并发症之一。目前尚未完全明确糖尿病外周血管病变的发病机制,且该病缺少有效的治疗手段和药物。脂肪因子对糖尿病及其并发症的发生发展有着深刻的影响,直接或间接地参与了糖尿病外周血管病变的进程。不同的脂肪因子或抑制血管病变的发生,或促进其发生,机制复杂且尚存在许多争议。脂肪因子有望成为治疗糖尿病外周血管病变的新靶点,值得进一步深入研究。该文主要对一些常见的脂肪因子和新型脂肪因子与糖尿病外周血管病变的关系进行综述,旨在为糖尿病外周血管病变的临床治疗提供新方法。Peripheral arterial disease is one of the common complications of diabetes.At present,the pathogenesis of diabetic peripheral arterial diseases is not completely clear,and there is a lack of effective treatment methods and drugs.Adipokines have profound impact on the occurrence and development of diabetes mellitus and its complications,and are directly or indirectly involved in the progression of diabetic peripheral arterial diseases.Different adipokines may inhibit or promote the occurrence of vascular diseases with the mechanisms that are complex and controversial.Adipokines are expected to be a new target for the treatment of diabetic peripheral arterial disease,which is worthy of further study.This article mainly reviews the relationship between some common adipokines and new adipokines and diabetic vascular disease,aiming to provide new methods for the clinical treatment of diabetic peripheral arterial disease.

关 键 词：糖尿病 外周血管疾病 脂肪因子类 药物相互作用 

分 类 号：R587.2[医药卫生—内分泌]