子痫前期血清FGF21、ITGβ-1及FOXA1的表达情况及与妊娠结局的相关性  

Effect of serum FGF21,ITGβ-1 and FOXA1 in preeclampsia and their correlation with pregnancy outcome

作　　者：郭君丽 尹玲凤 蒋伟菊 丁永霞 GUO Junli;YIN Lingfeng;JIANG Weiju;DING Yongxia(Department of Obstetrics and Gynecology,Nanjing Maternal and Child Health Hospital,Nanjing Jiangsu 210000,China)

机构地区：[1]南京市妇幼保健院妇产科,江苏南京210000

出　　处：《中国妇产科临床杂志》2024年第3期200-202,共3页Chinese Journal of Clinical Obstetrics and Gynecology

基　　金：2022年度南京市卫生科技发展专项资金项目(YKK22150)。

摘　　要：目的探讨子痫前期血清成纤维细胞生长因子-21(FGF21)、整合素β1(ITGβ-1)及叉头盒蛋白A1(FOXA1)的表达情况及与妊娠结局相关性。方法选择2021年3月至2023年2月南京市妇幼保健院接诊的150例子痫前期患者为研究对象,设为病例组,并选择同期在本院孕检的健康孕妇100例作为对照组,比较两组血清FGF21、ITGβ-1及FOXA1水平变化情况,妊娠结局及其之间的相关性分析。结果病例组血清FGF21、ITGβ-1及FOXA1水平较对照组更高,差异均有统计学意义(P<0.05);轻度组患者血清FGF21、ITGβ-1及FOXA1水平均显著低于重度组患者,差异有统计学意义(P<0.05);病例组不良妊娠结局发生率显著高于对照组,新生儿体重及Apgar评分显著低于对照组,差异有统计学意义(P<0.05);相关性分析结果显示,血清FGF21、ITGβ-1及FOXA1和新生儿窒息、早产儿、低出生体重儿之间均呈正相关,和新生儿体重、Apgar评分均呈负相关(P<0.05)。结论在子痫前期患者中血清FGF21、ITGβ-1及FOXA1的表达和不良妊娠结局间关系密切。Objective To study effect of serum Fibroblast growth factor-21(FGF21),integrinβ1(ITGβ-1)and FOXA1 in preeclampsia and their correlation with pregnancy outcome.Methods A total of 150 cases of preeclampsia patients admitted to Nanjing Maternal and Child Health Hospital from March 2021 to February 2023 were selected as the study subjects and set as the case group,and 100 healthy pregnant women from the pregnancy examination of undergoing concurrent pregnancy were selected as the control group.The changes of serum FGF21,ITGβ-1 and FOXA1 levels,pregnancy outcomes and their correlation analysis were compared.Results Serum levels of FGF21,ITGβ-1 and FOXA1in case group were significantly higher than those in control group(P<0.05);The serum levels of FGF21,ITGβ-1 and FOXA1 in mild group were significantly lower than those in severe group(P<0.05).The incidence of adverse pregnancy outcome in the case group was significantly higher than that in the control group,and the neonatal weight and Apgar score were significantly lower than those in the control group(P<0.05).Correlation analysis results showed that serum FGF21,ITGβ-1 and FOXA1 were positively correlated with neonatal asphyxia,premature infants and low birth weight infants,and negatively correlated with neonatal weight and Apgar score(P<0.05).Conclusion The expression of serum FGF21,ITGβ-1 and FOXA1 is closely related to adverse pregnancy outcomes in patients with preeclampsia.

关 键 词：子痫前期 成纤维细胞生长因子-21 整合素Β1 叉头盒蛋白A1 妊娠结局 相关性 

分 类 号：R714.244[医药卫生—妇产科学]