药用植物生物信息数据库及生产布局可视化分析平台(以川产道地药材为例)  

Bioinformatics database and production layout visual analysis platform of medicinal plants:a case study of Dao-di medicinal materials in Sichuan province

作　　者：华桦 田韦韦 马炅妤 王云峰[3] 王亚强[4] 严志祥 赵军宁 HUA Hua;TIAN Wei-wei;MA Jiong-yu;WANG Yun-feng;WANG Ya-qiang;YAN Zhi-xiang;ZHAO Jun-ning(Sichuan Institute for Translational Chinese Medicine,Sichuan Academy of Chinese Medical Sciences,Key Lab of Biological Evaluation of TCM Quality of the State Administration of Traditional Chinese Medicine,Translational Chinese Medicine Key Laboratory of Sichuan Province,Sichuan Engineering Technology Research Center of Genuine Regional Drug,Sichuan Provincial Engineering Research Center of Formation Principle and Quality Evaluation of Genuine Medicinal Materials,Chengdu 610041,China;Digital City Engineering Center,the Third Geographical Information Mapping Institute of Natural Resources Ministry,Chengdu 610100,China;Institute of Microelectronics of Chinese Academy of Sciences,Beijing 100029,China;Software Engineering Institute,Chengdu University of Information Technology,Chengdu 610225,China;National Key Laboratory of Drug Regulatory Science,National Medical Products Administration of China,Beijing 100037,China)

机构地区：[1]四川省中医药转化医学中心四川省中医药科学院国家中医药管理局中药质量生物学评价重点研究室中医药转化医学四川省重点实验室四川省道地药材系统开发工程技术研究中心四川省道地药材形成原理与品质评价工程研究中心,四川成都610041 [2]自然资源部第三地理信息制图院数字城市工程中心,四川成都610100 [3]中国科学院微电子研究所数字健康芯片与系统实验室,北京100029 [4]成都信息工程大学软件工程学院,四川成都610225 [5]国家药品监督管理局药品监管科学全国重点实验室,北京100037

出　　处：《中国中药杂志》2024年第8期1989-1995,共7页China Journal of Chinese Materia Medica

基　　金：四川省中医药科技产业创新团队专项(2022C009);四川省科技服务业平台资金项目(A-2022N-51);财政部、国家中医药管理局2017年中央财政中医药部门公共卫生服务补助资金项目(Z135080000022);四川省科技支撑计划项目(2013SZ0115);四川省中医药管理局2017年科技专项(2017C008);四川省中医药管理局2016年科技专项(2016Z011)。

摘　　要：目前对药用植物的研究和认识已进入到跨组学、跨学科智能新阶段,迫切需要将这些大数据进行整合并交互应用,形成统一、多层次的研究体系和大数据平台。道地药材作为一类重要的药用植物来源,是中医药特有的品质优劣概念和综合判别标准。国内外已建立中医药百科全书数据库(ETCM)、全球药典基因组数据库(GPGD)等为代表的数据库平台,但未能及时反映新近的大量地理资源、表型、化学成分和遗传信息等多维度数据。四川省是著名的“中医之乡,中药之库”,据四川省第四次全国中药资源普最新统计中药品种数超过8000种,川产道地药材品种86种,是我国药用植物多样性最具代表性的地区。该文基于四川省第四次全国中药资源普查最新数据及相关成果,以川产道地药材为例构建药用植物生物信息数据库及生产布局可视化分析平台,涵盖了地理资源数据、表型数据、化学成分数据和遗传资源数据等,有效地将川产道地药材多维度数据统一整合,并提供不同层面的数据交互应用。该平台不仅是首个针对川产道地药材的大型多维数据库和可视化平台,可为川产道地药材种质资源鉴定、药效成分生物合成途径解析、优良品种分子育种等奠定基础。该平台提供的以川产道地药材为代表的药用植物资源基础信息和数据支撑,对我国及全球药用植物开发利用也不无裨益。In the new stage of trans-omics and trans-subjects for medicinal plants,it is an urgent need to integrate big data,provide interactive applications,and form a unified and multi-level research system and big data platform.Dao-di medicinal material,as an important source of medicinal plants,is a unique quality concept and comprehensive standard of tranditional Chinese medicine(TCM).Several databases have been developed in China and abroad,such as the Encyclopedia of Traditional Chinese Medicine(ETCM)and the Global Pharmacopoeia Genome Database(GPGD).Yet,most databases do not provide multi-dimensional data,including geographic data,phenotype data,compound data,and genetic data.Sichuan,known as the hometown of TCM therapies and the treasure trove of TCM,is the most representative region of medicinal plant diversity in China.According to the latest data of the fourth national survey of TCM resources,there are more than 8000 TCM and 86 Dao-di medicinal materials in Sichuan province.Based on resource census data and relevant achievements,this study constructed the bioinformatics database of medicinal plants and the visual analysis platform of production layout by taking the Dao-di medicinal materials in Sichuan province as an example,covering geographic data,phenotype data,compound data,and genetic data.It effectively integrates multi-dimensional data of Dao-di medicinal materials and provides different levels of data interaction applications.The platform is the first large-scale multi-dimensional database and visual platform of Dao-di medicinal materials in Sichuan province,which serves as an essential resource for germplasm resources identification,decomposition of biosynthetic pathways,molecular breeding of varieties and provides medicinal plant resource information and data support for development and utilization of medicinal plants in China and abroad.

关 键 词：药用植物 川产道地药材 生产布局 生物信息 数据化 可视化 

分 类 号：S567[农业科学—中草药栽培]