荜茇酰胺抗肿瘤及其纳米给药系统研究进展  

Research progress in anti-tumor activity and nano-drug delivery system of piperlongumine

作　　者：张昊熙昱 林龙飞[2] 刘宇灵[2] 李慧 ZHANG Hao-xi-yu;LIN Long-fei;LIU Yu-ling;LI Hui(School of Pharmacy,Jiangxi University of Chinese Medicine,Nanchang 330004,China;Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences,Beijing 100700,China;Institute of Traditional Chinese Medicine Health Industry,China Academy of Chinese Medical Sciences,Nanchang 330000,China)

机构地区：[1]江西中医药大学药学院,江西南昌330004 [2]中国中医科学院中药研究所,北京100700 [3]中国中医科学院中医药健康产业研究所,江西南昌330000

出　　处：《中国中药杂志》2024年第8期2117-2127,共11页China Journal of Chinese Materia Medica

基　　金：国家重点研发计划中医药现代化研究重点专项(2022YFC3501900);中国中医科学院科技创新工程项目(CI2021B014,CI202104301,CI202104305);中央级公益性科研院所基本科研业务费专项(ZXKT21013)。

摘　　要：荜茇酰胺是一种来源于中药荜茇的天然生物碱成分,其抗肿瘤活性强且对正常细胞毒性小,与化疗、放疗联合具备优异的增敏作用,因此近些年来备受关注。但是荜茇酰胺水溶性低、生物利用度差等问题也严重阻碍了其在临床上的应用,构建荜茇酰胺纳米给药系统可以很好地改善上述问题。将荜茇酰胺及其纳米给药系统广泛用于多种癌症的治疗具有良好的应用前景。通过对近年来国内外文献中荜茇酰胺的理化性质、抗肿瘤作用机制、相关的联合治疗应用及其纳米给药系统的抗肿瘤研究进行整理,为荜茇酰胺及其纳米给药系统在抗肿瘤作用中的进一步研究及肿瘤治疗领域的发展应用提供参考借鉴。Piperlongumine(PL),a natural alkaloid extracted from Piperis Longi Fructus,has attracted much attention in recent years because of its strong anti-tumor activity,little toxicity to normal cells,and excellent sensitizing effect combined with chemotherapy and radiotherapy,which endow PL with unique advantages as an anti-tumor drug.However,similar to other alkaloids,PL has low water solubility and poor bioavailability.To improve the application of PL in the clinical treatment of tumors,researchers have constructed various nano-drug delivery systems to increase the efficiency of PL delivery.This paper reviewed the physicochemical properties,anti-tumor mechanism,combined therapies,and nano-drug delivery systems of PL in recent years.The review aimed to provide a reference for further research on the anti-tumor effect and nano-drug delivery system of PL.Moreover,this review is expected to provide a reference for the development and application of PL in the anti-tumor therapies.

关 键 词：荜茇酰胺 抗肿瘤 理化性质 作用机制 联合治疗 纳米给药系统 

分 类 号：R285[医药卫生—中药学]