N-烷氧基取代双酰胺类化合物的合成及杀虫活性  

Synthesis and insecticidal activity of N-alkoxy substituted diamide compounds

作　　者：王奥运 吴明慧 吕亮 相君成 庞怀林 彭鹏 黄朋勉[1] 刘吉永 WANG Aoyun;WU Minghui;LYU Liang;XIANG Juncheng;PANG Huailin;PENG Peng;HUANG Pengmian;LIU Jiyong(School of Chemistry and Chemical Engineering,Changsha University of Science and Technology,Changsha 410000,China;CAC Nantong Chemicals Co.,Ltd.,Nantong 226407,Jiangsu,China)

机构地区：[1]长沙理工大学化学化工学院,长沙410000 [2]南通泰禾化工股份有限公司,江苏南通226407

出　　处：《农药》2024年第5期319-324,共6页Agrochemicals

基　　金：湖南省教育厅科学研究项目(编号20A019)。

摘　　要：[目的]为寻找新的杀虫先导化合物。[方法]采用活性亚结构拼接方法,首次将N-烷氧基结构片段引入溴虫氟苯双酰胺中,设计合成了23个未见文献报道的结构新颖的双酰胺类化合物。[结果]目标化合物的结构均经过1H NMR和HRMS确证。部分化合物对小菜蛾和黏虫表现出了优异的防效,尤其是化合物1j、1s、1t在100 mg/L质量浓度下对小菜蛾和黏虫的致死率至少为90%。[结论]该类化合物表现出较好的杀鳞翅目害虫活性,本实验为双酰胺类化合物的结构丰富和新先导发现提供了有益的参考。[Aims]The aim of this study is to discover novel insecticidal lead compound.[Methods]Introducing N-alkoxy structural fragments into broflanilide for the first time by the active substructure splicing method,23 novel diamide compounds never reported in the literature were designed and synthesized.[Results]The structures of the title compounds were confirmed by 1 H NMR and HRMS.Some of them had excellent insecticidal activity against Plutella xylostella and Mythimna separata.Especially,compounds 1j,1s and 1t exhibited at least 90%mortality against P.xylostella and M.separata.[Conclusions]The compounds show good activity against lepidopteran pests.This study provides a useful reference for the structural enrichment and new lead discovery of diamide compounds.

关 键 词：合成 双酰胺 杀虫活性 先导发现 

分 类 号：TQ453.2[化学工程—农药化工]