新型乙烯基吡唑丙烯腈类化合物的合成及杀螨活性  

Synthesis and acaricidal activity of novel vinyl pyrazolyl acrylonitrile derivatives

作　　者：张斌 杨辉斌 常秀辉 宋玉泉 李斌 汪国庆 ZHANG Bin;YANG Huibin;CHANG Xiuhui;SONG Yuquan;LI Bin;WANG Guoqing(Shenyang Science Create Co.,Ltd.,Shenyang 110144,China;State Key Laboratory of the Discovery and Development of Novel Pesticide,National Engineering Research Center of Pesticide,Shenyang Sinochem Agrochemicals R&D Co.,Ltd.,Shenyang 110021,China)

机构地区：[1]沈阳科创化学品有限公司,沈阳110144 [2]沈阳中化农药化工研发有限公司新农药创制与开发国家重点实验室,农药国家工程研究中心,沈阳110021

出　　处：《农药》2024年第5期325-329,共5页Agrochemicals

摘　　要：[目的]为了发现结构新颖的杀螨活性化合物。[方法]以腈吡螨酯为先导化合物,在丙烯腈结构中引入乙烯基吡唑结构片断,设计合成了15个新型乙烯基吡唑丙烯腈类化合物,并对其进行杀螨活性测试。[结果]初步的室内生物活性测试结果表明:目标化合物6a~6h均表现出较好的杀螨活性,在100 mg/L质量浓度下对朱砂叶螨致死率均≥99%。其中化合物6 g表现最佳,在10 mg/L下对朱砂叶螨致死率仍为88%。[结论]当羟基上的H被烷基羰基、烷氧基羰基取代时,化合物具有较好的杀螨活性。[Aims]This study aims to discover novel compounds with acaricidal activity.[Methods]Using cyenopyrafen as lead compound,15 novel vinyl pyrazolyl acrylonitrile derivatives were designed and synthesized by introducing vinyl pyrazole into acrylonitrile structure,and their acaricidal activity were tested.[Results]Results of preliminary bioassay in green house showed that target compounds 6a-6h exhibited good acaricidal activities against Tetranychus cinnabarinus at 100 mg/L,with mortality rates of≥99%.Compound 6g showed the best acaricidal activity,with a mortality rate of 88%at 10 mg/L.[Conclusions]When the H of the hydroxyl is substituted by alkylcarbonyl or alkoxycarbonyl,the resulting compounds exhibit good acaricidal activity.

关 键 词：乙烯基吡唑 丙烯腈 合成 杀螨活性 

分 类 号：TQ454.2[化学工程—农药化工]