HLA基因多态性与乙型肝炎疫苗免疫效果和安全性的研究进展  

Research progress on HLA gene polymorphism and immune efficacy and safety of hepatitis B vaccine

作　　者：王卫平 白雨 冯勇 程琬然 杨天 邓鹏飞 WANG Weiping;BAI Yu;FENG Yong;CHENG Wanran;YANG Tian;DENG Pengfei(Department of Immunoprophylaxis,Shanghai Pudong New Area Center for Disease Control and Prevention,Pudong Institute of Preventive Medicine,Fudan University,Shanghai,200136,China)

机构地区：[1]上海市浦东新区疾病预防控制中心免疫预防科,复旦大学浦东预防医学研究院,上海200136

出　　处：《职业与健康》2024年第6期856-859,864,共5页Occupation and Health

基　　金：上海市浦东新区卫生健康委员会重点学科(PWZxk2022-25);上海市优秀青年人才项目(GWV-10.2-YQ38);上海市浦东疾控中心(复旦大学浦东预防医学研究院)专项(YJY-2024-03);上海市浦东新区科技发展基金项PKJ2023-Y34。

摘　　要：近年来,人类白细胞抗原(human leukocyte antigen,HLA)基因在乙型肝炎疫苗免疫效果相关性被诸多医疗专家所关注。本文就HLA基因在乙型肝炎疫苗免疫效果的相关研究进行总结和归纳,探讨HLA基因多态性与乙型肝炎肝疫苗免疫反应和不良反应关系,总结不同HLA基因对乙型肝炎疫苗免疫效果的相关机制,为不同HLA人群乙型肝炎疫苗的个性化疫苗接种提供科学依据,现就HLA基因概况、乙型肝炎病毒(hepatitis B virus,HBV)疫苗应答效果及其相关机制等作一综述。In recent years,the correlation of human leukocyte antigen(HLA)gene in the immune effect of hepatitis B vaccine has been concerned by many medical experts.This article summarizes the related research of HLA gene in the immune effect of hepatitis B vaccine,discusses the relationship between HLA gene polymorphism and immune response and adverse reactions of hepatitis B vaccine,summarizes the related mechanism of different HLA genes on the immune effect of hepatitis B vaccine,and provides a scientific basis for personalized vaccination of hepatitis B vaccine in different HLA populations.This article reviews the general situation of HLA gene,the response effect of HBV vaccine and its related mechanism.

关 键 词：人类白细胞抗原 基因多态性 乙型肝炎 疫苗 

分 类 号：R512.62[医药卫生—内科学] R392[医药卫生—临床医学]