Sol-gel derived B_(2)O_(3)-CaO borate bioactive glasses with hemostatic,antibacterial and pro-angiogenic activities  

作　　者：Kai Zheng Faina Bider Mahshid Monavari Zhiyan Xu Christina Janko Christoph Alexiou Ana M.Beltran Aldo R.Boccaccini 

机构地区：[1]Jiangsu Province Engineering Research Center of Stomatological Translational Medicine,College of Stomatology,Nanjing Medical University,Nanjing 210029,China [2]Jiangsu Key Laboratory of Oral Diseases,Nanjing Medical University,Nanjing 210029,China [3]Institute of Biomaterials,University of Erlangen-Nuremberg,91058 Erlangen,Germany [4]Department of Oto-Rhino-Laryngology,Head and Neck Surgery,Section of Experimental Oncology and Nanomedicine(SEON),Else Kroener-Fresenius-Stiftung Professorship,Universitaetsklinikum Erlangen,91058 Erlangen,Germany [5]Departamento de Ingenier�ıa y Ciencia de los Materiales y del Transporte,Escuela Politecnica

出　　处：《Regenerative Biomaterials》2024年第1期108-118,共11页再生生物材料（英文版）

基　　金：funding from DFG(German Science Foundation),Project:BO1191/23;the Manfred Roth Foundation,Furth,the Forschungsstiftung Medizin am Universitatsklinikum Erlangen and Hans Wormser,Herzogenaurach,Germany.

摘　　要：Sol-gel borate bioactive glasses(BGs)are promising ion-releasing biomaterials for wound healing applications.Here,we report the synthesis of a series of binary B_(2)O_(3)-CaO borate BGs(CaO ranging from 50 to 90mol%)using a sol-gel-based method.The influence of CaO content in B_(2)O_(3)-CaO borate BG on morphology,structure and ion release behavior was investigated in detail.Reduced dissolution(ion release)and crystallization could be observed in borate BGs when CaO content increased,while the morphology was not significantly altered by increasing CaO content.Our results evidenced that the ion release behavior of borate BGs could be tailored by tuning the B_(2)O_(3)/CaO molar ratio.We also evaluated the in vitro cytotoxicity,hemostatic,antibacterial and angiogenic activities of borate BGs.Cytocompatibility was validated for all borate BGs.However,borate BGs exhibited composition-dependent hemostatic,antibacterial and angiogenic activities.Generally,higher contents of Ca in borate BGs facilitated hemostatic activity,while higher contents of B_(2)O_(3) were beneficial for pro-angiogenic activity.The synthesized sol-gel-derived borate BGs are promising materials for developing advanced wound healing dressings,given their fast ion release behavior and favorable hemostatic,antibacterial and angiogenic activities.

关 键 词：borate glasses sol-gel processing glass composition wound healing 

分 类 号：R318[医药卫生—生物医学工程]