深圳市坪山区2019—2022年VCT人群血液传染病病原构成及变迁研究  

Pathogen composition and changes of blood infectious diseases in VCT population in Pingshan District,Shenzhen from 2019 to 2022

作　　者：刘晓岑 罗亮 严彩莲 林苇婷 吴晓霞 LIU Xiaocen;LUO Liang;YAN Cailian;LIN Weiting;WU Xiaoxia(Pingshan District Center for Disease Control and Prevention,Shenzhen,Guangdong 518118,China)

机构地区：[1]坪山区疾病预防控制中心,广东深圳518118

出　　处：《中国国境卫生检疫杂志》2024年第2期196-200,共5页Chinese Journal of Frontier Health and Quarantine

基　　金：深圳市坪山区卫生系统科研基金项目(202087)。

摘　　要：目的研究深圳市坪山区2019—2022年自愿咨询检测(voluntary counseling and testing,VCT)人群中血液传染病病原构成及变迁,为VCT人群中血液传染病的精准防控提供科学依据。方法对VCT人群参照《中国艾滋病诊疗指南(2018版)》检测人类免疫缺陷病毒(HIV)抗体,采用酶联免疫吸附法(ELISA)检测梅毒螺旋体(TP)、丙肝病毒(HCV)抗体及乙肝病毒表面抗原(HBsAg),统计上述4种病原构成及变化特征。结果共检测VCT标本533份,病原阳性率为21.76%,各年间差异无统计学意义(χ^(2)=4.166,P=0.244)。阳性人群主要是有性行为相关危险史的中青年男性,但不同人口学特征人群阳性率差异均无统计学意义。感染类型包括单独感染、双重感染和三重感染,HIV单重感染(8.44%)、TP单重感染(9.01%)及HBsAg单独携带(7.88%)、HCV感染(0.56%)、HIV+TP感染(2.81%)、HIV+HBsAg感染(1.31%)、TP+HBsAg感染(0.38%)及HIV+TP+HBsAg三重感染(0.38%)的阳性率差异有统计学意义(χ^(2)=153.311,P<0.001);单重感染阳性率差异无统计学意义(χ^(2)=0.208,P=0.901)。结论深圳市坪山区2019—2022年VCT人群中存在4种血液传染病病原体感染,不同感染类型阳性率及年度阳性人群构成差异主要集中在危险行为史,可根据以上特征制定血液传染病防控措施。Objective To study the pathogen composition and changes of blood-borne infectious diseases among voluntary counseling and testing(VCT)population in Pingshan District,Shenzhen from 2019 to 2022,and to provide scientific basis for the accurate prevention and control of blood-borne infectious diseases among VCT population.Methods The human immunodeficiency virus(HIV)antibody in the VCT population was detected according to“Chinese AIDS Diagnosis and Treatment Guide(2018 edition)”,Treponema pallidum(TP),hepatitis C virus(HCV)antibody and hepatitis B virus surface antigen(HBsAg)were detected by ELISA.The composition and change characteristics of the above 4 pathogens were analyzed.Results A total of 533 VCT samples were detected,the positive rate of pathogens was 21.76%,with no significant difference between different years(χ^(2)=4.166,P=0.244).The positive population was mainly middle-aged and young men with history of risk sexual behavior,but there was no significant difference in the positive rate among different demographic groups.The types of infection included single infection,double infection and triple infection.The differences in positive rate among HIV single infection(8.44%),TP single infection(9.01%)and HBsAg alone(7.88%),HCV infection(0.56%),HIV+TP infection(2.81%),HIV+HBsAg infection(1.31%),TP+HBsAg infection(0.38%)and HIV+TP+HBsAg triple infection(0.38%)were statistically significant(χ^(2)=153.311,P<0.001),the difference of positive rate in single infection was not statistically significant(χ^(2)=0.208,P=0.901).Conclusion There were four kinds of blood-borne infectious disease pathogens in VCT population in Pingshan District of Shenzhen,2019-2022,and the difference of the positive rate of different infection types and the annual positive population composition changed mainly focused on the history of risk behavior.More prevention and control measures for blood-borne infectious diseases could be developed according to the above characteristics.

关 键 词：自愿咨询检测 血液传染病 病原 

分 类 号：R183[医药卫生—流行病学]