2015—2022年某院耐碳青霉烯大肠埃希菌分布及耐药性分析  

Distribution and drug resistance analysis of carbapenem resistant Escherichia coli in a hospital from 2015 to 2022

作　　者：伊怀文[1] 梁志强[1] 江玉凤 李仁哲[1] 侯高林 YI Huaiwen;LIANG Zhiqiang;JIANG Yufeng;LI Renzhe;HOU Gaolin(Department of Medical Laboratory,The First People's Hospital of Jining,Jining,Shandong 272100,China;不详)

机构地区：[1]山东省济宁市第一人民医院医学检验科,山东济宁272100 [2]山东省济宁市第一人民医院生殖医学科,山东济宁272100

出　　处：《中国国境卫生检疫杂志》2024年第2期211-214,共4页Chinese Journal of Frontier Health and Quarantine

基　　金：山东省医药卫生科技发展计划项目(鲁卫函(2021)446)。

摘　　要：目的分析耐碳青霉烯大肠埃希菌的分布特征及耐药性变迁,为科学防控院内感染提供科学依据。方法回顾性分析2015年1月—2022年12月济宁市第一人民医院临床送检标本中分离出的耐碳青霉烯类大肠埃希菌的分布及药敏试验。临床标本(呼吸道标本、血液、尿液、分泌物、无菌体液等)送检后,单菌落使用全自动细菌鉴定药敏仪进行鉴定和药敏试验,确定耐碳青霉烯类大肠埃希菌;根据标本信息确定科室分布、标本类型分布;根据药敏试验确定各抗菌药物的耐药率。结果2015—2022年共检出大肠埃希菌10271株,其中耐碳青霉烯大肠埃希菌196株(1.91%)。在检出的患者中,男性(57.65%)多于女性(42.35%);检出科室中,检出最多的是重症监护室(41.33%);标本分布中,尿液标本检出最多(49.49%);耐碳青霉烯大肠埃希菌对常用抗菌药物呈现出高耐药率,β-内酰胺类抗菌药物(除氨曲南外)耐药率均达到100%;氨基糖苷类抗菌药物阿米卡星的耐药率略低(≤31%)。结论医院耐碳青霉烯大肠埃希菌检出率高,细菌耐药广泛,应合理应用抗菌药物,避免院内感染。Objective To analyze the distribution characteristics and drug resistance changes of carbapenem resistant Escherichia coli,and to provide basis for scientific prevention and control of hospital infections.Methods A retrospective study was used to analyze the distribution and drug sensitivity test of carbapenem resistant Escherichia coli isolated from clinical samples submitted to Jining First People's Hospital from January 2015 to December 2022.After the clinical samples(respiratory samples,blood,urine,secretions,sterile body fluids)were submitted for examination,single colonies were isolated by using fully automated bacterial identification and drug sensitivity tester for identification and drug sensitivity testing,carbapenem resistant Escherichia coli was identified.The distribution of departments and sample types were determined according to the sample information,the drug resistance rate of each antibiotic was determined according to drug sensitivity test.Results A total of 10271 strains of Escherichia coli were detected from 2015 to 2022,including 196 strains(1.91%)of carbapenem resistant Escherichia coli.Among the detected patients,males(57.65%)were more than females(42.35%).Among the detection positive departments,the intensive care unit was the most one(41.33%).Among the samples distribution,urine samples were the most detected positive(49.49%).Carbapenem resistant Escherichia coli showed high rate of resistant to commonly used antibiotics.The drug resistance rate ofβ-lactam antibiotics(except for aztreonam)reached 100%,the resistance rate was lower(≤31%)of aminoglycoside antibiotic amikacin.Conclusion The positive rate of carbapenem resistant Escherichia coli in the hospital was high,and the bacteria were widely resistant to antibiotics.Therefore,antibiotics should be used reasonably to avoid hospital infection.

关 键 词：碳青霉烯 大肠埃希菌 院内感染 革兰阴性杆菌 药敏试验 

分 类 号：R183[医药卫生—流行病学] R446.5[医药卫生—公共卫生与预防医学]