2021年河南省1~5岁儿童乙型病毒性肝炎血清标志物监测结果  

Results of hepatitis B serum marker surveillance among children aged 1-5 years in Henan in 2021

作　　者：豆巧华 张璐[1,2] 杨凯朝 吕宛玉 杨建辉 郭永豪[1,2] 刘倩 丰达星[1,2] 赵升 徐瑾[1,2] 张延炀 DOU Qiaohua;ZHANG Lu;YANG Kaichao;LYU Wanyu;YANG Jianhui;GUO Yonghao;LIU Qian;FENG Daxing;ZHAO Sheng;XU Jin;ZHANG Yanyang(Henan Center for Disease Control and Prevention,Henan 450016,China;Henan Provincial Key Medical Laboratory of Immunoprophylaxis)

机构地区：[1]河南省疾病预防控制中心,河南郑州450016 [2]河南省免疫预防医学重点实验室

出　　处：《现代疾病预防控制》2024年第4期247-250,296,共5页MODERN DISEASE CONTROL AND PREVENTION

基　　金：河南省自然科学基金项目(222300420466);河南省医学科技攻关省部共建项目(2018010028);河南省医学科技攻关计划联合共建项目(LHGJ20210150)。

摘　　要：目的了解和分析2021年河南省不同地区1~5岁儿童乙型病毒性肝炎(乙肝)血清标志物的流行状况,评价河南省儿童免疫规划实施的效果。方法2021年采用横断面调查方法,在河南省18个省辖市的27个县(市、区)随机抽取1776名1~5岁儿童作为调查对象,开展乙型肝炎免疫状况评估,采用酶联免疫吸附试验检测血清中乙肝表面抗原(HBsAg)、乙肝表面抗体(HBsAb)、乙肝核心抗体(HBcAb)。结果2021年河南省共调查1~5岁儿童1776名,HBsAg、HBsAb、HBcAb标化阳性率分别为0.15%、74.26%、12.48%。1~5岁各年龄段HBsAb阳性率均>78.00%,随着年龄的增长HBsAb阳性率逐渐降低(χ^(2)_(趋势)=67.833,P<0.05),1~<3岁儿童HBsAb阳性率>90.00%。不同年龄、不同地区、不同接种剂次儿童HBsAb和HBcAb阳性率均存在统计学差异(P均<0.05)。河南省1~5岁乙肝病毒(HBV)易感人群占比为13.18%(234/1776)。结论河南省1~5岁儿童HBsAg流行率维持在较低水平,年龄、地区、接种剂次对HBsAb、HBcAb阳性率有显著影响,建议各地市密切监测HBsAg流行率。Objective To understand the prevalence of serum hepatitis B virus(HBV)biomarkers among children aged 1-5 in different regions of our province,and evaluate the implementation effect of Henan provincial Immunization Plan for Children.Methods In 2021,a cross-sectional survey was conducted selecting 1776 children aged 1-5 years as study subjects randomly in27 counties/cities/districts of 18 cities under the jurisdiction of Henan province.The immunization status of hepatitis B was evaluated.Serum hepatitis B surface antigen(HBsAg),hepatitis B surface antibody(HBsAb)and hepatitis B core antibody(HBcAb)were detected with ELISA method.Results The standardized positive rates of HBsAg,HBsAb,and HBcAb among children aged 1-5 years in Henan province were 0.15%,74.26%,and 12.48%,respectively.The positive rates of HBsAb in every group aged 1-5 years were all more than 78.00%,and the positive rate of HBsAb gradually decreased with the increase of age(χ^(2)_(trend)2=67.833,P<0.05);the positive rate among children aged 1-<3 years and younger was more than 90.00%.There were statistically significant differences in the positive rates of HBsAb among children with different age groups,different regions and different hepatitis B vaccination histories(all P<0.05).The proportion of HBV susceptible population among children aged 1-5 in Henan province was 13.18%(234/1776).Conclusions The prevalence of HBsAg in children aged 1-5 years in Henan province remains at a low level,and age,region,and hepatitis B vaccination history have a significant impact on the positivity rates of HBsAb and HBcAb.It is recommended to closely monitor the prevalence of HBsAg in all regions.

关 键 词：河南省 1~5岁 乙肝 

分 类 号：R512.62[医药卫生—内科学]