2019—2022年郑州市人乳头瘤病毒疫苗疑似预防接种异常反应监测结果  

Monitoring results of adverse events following immunization of human papillomavirus vaccine in Zhengzhou city from 2019 to 2022

作　　者：范张洁 李锋[1] 许海燕 王小丽 原宏 孟庆玉[1] 王萌[1] 王瑞 王雨润 姚莹莹 乔丹 FAN Zhangjie;LI Feng;XU Haiyan;WANG Xiaoli;YUAN Hong;MENG Qingyu;WANG Meng;WANG Rui;WANG Yurun;YAO Yingying;QIAO Dan(Zhengzhou Center for Disease Control and Prevention,Zhengzhou,Henan 450007,China)

机构地区：[1]郑州市疾病预防控制中心免疫规划所,河南郑州450007

出　　处：《现代疾病预防控制》2024年第4期313-317,共5页MODERN DISEASE CONTROL AND PREVENTION

摘　　要：目的分析2019—2022年郑州市适龄女性接种人乳头瘤病毒(HPV)疫苗后出现疑似预防接种异常反应的发生情况。方法通过中国疾病预防控制信息系统收集2019—2022年郑州市报告的HPV疫苗疑似预防接种异常反应(AEFI)个案信息,通过河南省免疫规划信息管理系统以及郑州市智慧公共卫生系统收集HPV疫苗接种剂次数据,采用描述性流行病学方法进行分析。结果2019—2022年郑州市HPV疫苗疑似预防接种异常反应的年均报告发生率为4.57/10万剂,HPV2、HPV4、HPV9的报告发生率分别为3.42/10万剂、3.55/10万剂、6.38/10万剂,差异有统计学意义(P<0.05)。一般反应、异常反应、偶合症的报告发生率分别为4.17/10万剂、0.30/10万剂、0.10/10万剂。新密市、荥阳市和金水区报告发生率较高,分别为11.78/10万剂、8.96/10万剂、8.94/10万剂。9~<17岁人群报告发生率较高,为11.37/10万剂;各月均有病例报告,4~<7月报告发生率最高,为6.99/10万剂,不同年龄组、不同月份报告发生率差异有统计学意义(P均<0.05)。AEFI病例全部在0~24 h发生,其中65.22%在接种后0~<12 h发生。接种HPV疫苗第2剂次后发生异常反应的占50.00%,12~24 h发生异常反应的占66.67%。结论郑州市2019—2022年HPV疫苗不良反应以一般反应为主,报告发生率低,预防接种安全性良好。Objective To analyze the occurrences of adverse event following immunization(AEFI)for inoculation of human papillomavirus(HPV)vaccine in Zhengzhou city from 2019 to 2022.Methods The AEFI case data from 2019 to 2022 in Zhengzhou city were collected through China Disease Prevention and Control Information System.The HPV vaccine dose data were collected through Henan Provincial Immunization Program Information Management System and Zhengzhou Smart Public Health System.The descriptive epidemiological study was used to analyze.Results The average annual reported incidence of AEFI after HPV vaccination from 2019 to 2022 in Zhengzhou city was 4.57/10~5doses,The reported incidences of AEFI caused by HPV2,HPV4 and HPV9 vaccination were 3.42/10~5doses,3.55/10~5doses and 6.38/10~5doses,respectively.The difference was statistically significant(P<0.05).The incidence was 4.17/10~5doses for general reaction,0.30/10~5doses for abnormal reactions and0.10/10~5doses for coincidence reaction.The higher reported incidence rates in Xinmi city,Xingyang city and Jinshui district were 11.78/10~5doses,8.96/10~5doses and 8.94/10~5doses,respectively.The incidence was relatively high in the 9-16 age group,which was 11.37/10~5doses.AEFI cases were reported every month.The highest incidence was reported from April to June,which was 6.99/10~5doses.There were statistically significant differences in reported incidence among different age groups and different months(all P<0.05).All AEFI cases occurred between 0-24 hours,and 65.22%of them occurred less than 12 hours after inoculation.The abnormal reactions resulted from the second dose of HPV vaccine accounted for 50.00%,and 66.67%abnormal reactions occurred after 12-24 hours.Conclusions The HPV vaccine had a low reported incidence of AEFI in Zhengzhou from2019-2022,and the main AEFI was general reaction.The HPV vaccination is safe.

关 键 词：人乳头瘤病毒 疫苗接种 疑似预防接种异常反应 监测 

分 类 号：R186.3[医药卫生—流行病学]