2018一2022年新疆某市新报告HIV/AIDS新发感染分析  

Analysis of newly reported HIV/AIDS in a city of Xinjiang from 2018 to 2022

作　　者：高璇 毕洪波 赵燕艳 曾长玉 金涛[1] 洪拉木江·阿散 热汗古丽·艾力 王吉亮[1] GAO Xuan;BI Hong-bo;ZHAO Yan-yan;ZENG Chang-yu;JIN Tao;Honglamujiang ASAN;Rehanguli AILI;WANG Ji-liang(The Center for Disease Control and Prevention of Xinjiang Uygur Autonomous Region,Urumqi,Xinjiang 830002,China;Health Conmmision of Xinjiang Uygur Autonomous Region,Urumqi,Xinjiang 8300ll,China;不详)

机构地区：[1]新疆维吾尔自治区疾病预防控制中心,乌鲁木齐830002 [2]新疆维吾尔自治区卫生健康委员会,乌鲁木齐830001 [3]库车市疾病预防控制中心,新疆库车842000

出　　处：《疾病预防控制通报》2024年第2期8-11,21,共5页Bulletin of Disease Control & Prevention(China)

基　　金：新疆艾滋病防控研究重点实验室项目(XJYS1706);新疆维吾尔自治区公益性科研项目(KY2020099)。

摘　　要：目的分析2018一2022年新疆某市新报告HIV/AIDS病例基本情况、免疫印迹法(westernblot,WB)带型及CD4^(+)T细胞计数,探讨新发感染带型特征及免疫状态相关性。方法收集2018—2022年新疆某市新报告HIV/AIDS病例资料及CD4^(+)T细胞计数、WB检测和新发感染(限制性抗原亲和力酶联免疫法,LAg-AvidityEIA)检测结果,采用卡方检验、Logistic回归等方法进行统计学分析。结果共有688例新报告HIV/AIDS病例,以男性、农民、初中文化程度和经性传播为主,新发感染133例、占19.33%。单因素分析显示,新发感染者样本中gp41检出率(Wald χ^(2)=16.101)和p31检出率(Waldχ^(2)=8.005)低于既往感染样本(P<0.05),多因素Logistic回归分析显示,gp41条带缺失被判定为新发感染的可能性是出现gp41条带的3.847倍(OR=3.847,95%CI:1.780~8.314)。在不同免疫缺陷组中p51和p17检出率差异均有统计学意义(P<0.05)。结论WB带型与机体免疫状态存在相关性,gp41条带缺失可能是新发感染者WB带型的表象之一。Objective To analyze the basic situation,(western blot)WB banding pattern and CD4^(+)T cell count of newly reported HIV infected patients in a city of Xinjiang from 2018 to 2022,and explore the correlation between the characteristics of recent infection banding pattern and the immune status.Methods The data of newly reported HIV/AIDS cases from 2018 to 2022 and the results of CD4^(+)T cell count,WB test and new infection test(LAg-Avidity EIA)were collected and analyzed with Chi-square and Logistic regression methods.ResultsThere were all 688 newly reported HIV/AIDS patients.The male,farmer,junior high school education and sexual transmission were the main,with 133 newly infected cases,accounting for 19.33%.Univariate analysis showed that the positive rates of gp41(Wald χ^(2)=16.101)and p31(Wald χ^(2)=8.005)in the newly infected samples was lower than that in previous infected samples(P<0.05).Multiple Logistic regression analysis showed that the deletion of gp41 band was 3.847 times more likely to be identified as a new infection than the appearance of gp41 band(OR=3.847,95%CI:1.780-8.314).There were statistical differences in the detection rates of p51 and p17 in different immunosuppressive groups(P<0.05).Conclusions There is correlation between the WB banding pattern and the immune status of the patients.The deletion of gp41 band may be one sign of WB band pattern of newly infected patients.

关 键 词：HIV-1 WB带型 新发感染 LAg-AvidityEIA 

分 类 号：R512.91[医药卫生—内科学]