小花清风藤中生物碱类成分的研究  

Study on alkaloids isolated from Sabia parviflora

作　　者：朱仝飞[1,2] 朱小庆 李志峰 孙庆文[4] 李萍 胡荣[1,2] 闫志慧 王玉霞 ZHU Tongfei;ZHU Xiaoqing;LI Zhifeng;SUN Qingwen;LI Ping;HU Rong;YAN Zhihui;WANG Yuxia(Chongqing Medical and Pharmaceutical College,Chongqing 401331,China;Chongqing Engineering Research Center of Pharmaceutical Sciences,Chongqing 401331,China;Jiangxi University of Traditional Chinese Medicine,Nanchang 330006,China;Guizhou University of Traditional Chinese Medicine,Guiyang 550025,China)

机构地区：[1]重庆医药高等专科学校,重庆401331 [2]重庆市药物制剂工程技术研究中心,重庆401331 [3]江西中医药大学,江西南昌330006 [4]贵州中医药大学,贵州贵阳550025

出　　处：《中国药物化学杂志》2024年第2期120-125,共6页Chinese Journal of Medicinal Chemistry

基　　金：重庆市自然科学基金面上项目(cstc2021jcyj-msxmX0665);重庆市教委科学技术研究计划项目(KJQN202202803)。

摘　　要：目的对小花清风藤Sabia parviflora中的生物碱类成分进行研究。方法采用硅胶柱色谱、Sephadex LH-20色谱、制备薄层色谱及重结晶等方法,对小花清风藤中的化学成分进行分离纯化,根据理化性质和波谱数据分析鉴定化合物结构。结果从小花清风藤中分离得到12个化合物,分别鉴定为N-反式阿魏酰基-3-甲氧基酪胺(1)、N-顺式阿魏酰基-3-甲氧基酪胺(2)、cassythicine(3)、litseglutine A(4)、鹅掌楸碱(5)、荷叶碱(6)、莲明碱(7)、白鲜碱(8)、γ-崖椒碱(9)、venoterpine(10)、桂皮酰胺(11)、莲碱(12)。结论化合物1~11为首次从清风藤属植物中分离得到,化合物12为首次从小花清风藤中分离得到。The alkaloids of Sabia parviflora were separated and purified with chromatographic and recrystallization methods.Their structures were elucidated by spectroscopic methods and chemical analyses.As the result,twelve compounds were isolated from the Sabia parviflora and identified as N-trans-feruloyl-3'-methoxytyramine(1),N-cis-feruloyl-3'-methoxytyramine(2),cassythicine(3),litseglutine A(4),liriodenine(5),nuciferine(6),lysicamine(7),dictamnine(8),γ-fagarine(9),venoterpine(10),cinnamamide(11)and roemerine(12).Among them,compounds 1-11 were isolated from the plants of Sabia Colelbr.for the first time,and compound 12 was isolated from Sabia parviflora for the first time.

关 键 词：小花清风藤 化学成分 生物碱 鹅掌楸碱 

分 类 号：R284[医药卫生—中药学]