阻塞性睡眠呼吸暂停与眼部疾病相关性研究现状  

Research status of the relationship between obstructive sleep apnea and eye diseases

作　　者：刘旭[1] 胡克[1] Liu Xu;Hu Ke(Department of Respiratory and Critical Care Medicine,Renmin Hospital of Wuhan University,Wuhan 430060,China)

机构地区：[1]武汉大学人民医院呼吸与危重症医学科,武汉430060

出　　处：《国际呼吸杂志》2024年第4期478-483,共6页International Journal of Respiration

基　　金：国家自然科学基金(82270101)。

摘　　要：眼部疾病发病率高,对生活和工作的影响大,甚至致残,疾病负担重。诸多资料表明,部分眼病的发生和发展与睡眠呼吸障碍相关。阻塞性睡眠呼吸暂停(OSA)增加多种眼病的风险,包括青光眼、非动脉缺血性视神经病变、中心性浆液性脉络膜视网膜病变、糖尿病视网膜病变、眼睑松弛综合征和视网膜静脉闭塞;机制方面,主要与OSA特征性间歇低氧及睡眠片断化等所致氧化应激和缺氧性损伤、全身性炎症、交感神经张力升高和内皮功能障碍有关。OSA已成为许多眼病另一种潜在危险因素。本文系统地介绍OSA与眼部疾病相关的现有研究结果,以及两者之间的可能发病机制。Eye disease has high incidence,exerts great influence on life and work,even causes disability,and can lead to heavy disease burden.A lot of data show that the occurrence and development of some eye diseases are related to sleep-disordered breathing,and obstructive sleep apnea(OSA)increases the risk of many eye diseases,including glaucoma,non-arterial ischemic optic neuropathy,central serous chorioretinopathy,diabetic retinopathy,eyelid laxity syndrome,and retinal vein occlusion.The mechanism mainly involves oxidative stress and hypoxic injury,systemic inflammation,sympathetic nervous system hypertonia,and endothelial dysfunction induced by OSA-characterized intermittent hypoxia and sleep fragmentation.OSA has become another potential risk factor for many eye diseases.This article reviews the current research findings on the association between OSA and ocular diseases,and the possible pathogenesis.

关 键 词：睡眠呼吸暂停 阻塞性 青光眼 视神经病变 缺血性 中心性浆液性脉络膜视网膜病变 糖尿病视网膜病变 眼睑松弛综合征 视网膜静脉闭塞 

分 类 号：R766[医药卫生—耳鼻咽喉科] R77[医药卫生—临床医学]