PD-1/PD-L1途径介导的髓源性抑制细胞在脓毒症免疫抑制中作用的研究进展  

Research advances of myeloid-derived suppressor cells mediated by programmed death-1/programmed death-ligand 1 pathway in sepsis-induced immunosuppression

作　　者：许亦菲 臧学峰 陈炜 Xu Yifei;Zang Xuefeng;Chen Wei(Department of Critical Care Medicine,Beijing Shijitan Hospital,Capital Medical University,Beijing 100038,China)

机构地区：[1]首都医科大学附属北京世纪坛医院重症医学科,北京100038

出　　处：《中华危重病急救医学》2024年第3期332-336,共5页Chinese Critical Care Medicine

基　　金：北京市重大疫情防治重点专科建设类项目(ZDYQFZZDZK)。

摘　　要：脓毒症是由于机体对于感染反应失调导致的危及生命的器官功能障碍。脓毒症的免疫抑制阶段也是导致脓毒症晚期患者高病死率的重要原因。髓源性抑制细胞(MDSC)作为异质性的Gr1+CD11b+的未成熟细胞群,与具有免疫抑制特性的程序性细胞死亡受体-1(PD-1)及其配体(PD-L1)在脓毒症晚期免疫过程中发挥重要作用。本文就近年来有关PD-1/PD-L1途径介导的MDSC在脓毒症免疫抑制中作用的研究进展进行简要综述,阐述二者在免疫抑制阶段发挥作用的机制、PD-1/PD-L1途径通过信号通路和细胞因子对MDSC"双信号"模型的影响以及PD-1/PD-L1途径在脓毒症中发挥介导作用的时程。Sepsis is a life-threatening organ dysfunction due to dysregulation of the body's response to infection.The immunosuppressive phase of sepsis is also an important cause of high morbidity and mortality in patients with advanced sepsis.Myeloid-derived suppressor cell(MDSC),as a heterogeneous population of Gr1+CD11b+immature cells,play a pivotal role in the immune process of advanced sepsis together with programmed death-1(PD-1)and programmed death-ligand 1(PD-L1)with immunosuppressive properties.This review summarized the research progress of PD-1/PD-L1 pathway-mediated mechanism of MDSC in septic immunosuppression in recent years.The mechanism of action of PD-1/PD-L1 pathway in the immunosuppressive stage,the effects of PD-1/PD-L1 pathway on the"dual-signaling"model of MDSC through the signaling pathway and cytokines,as well as the time course of PD-1/PD-L1 pathway mediation in sepsis were described.

关 键 词：脓毒症 免疫抑制 髓源性抑制细胞 程序性死亡受体-1 程序性死亡配体-1 

分 类 号：R459.7[医药卫生—急诊医学]