退变椎间盘神经长入的研究进展  

Research progress in nerve ingrowth in intervertebral disc degeneration

作　　者：王少康 陆向东[2] 赵晓峰[2] 范伟[2] WANG Shao-kang;LU Xiang-dong;ZHAO Xiao-feng;FAN Wei(Shanxi Medical University,Taiyuan 030000,China;Department of Orthopedics,The Second Hospital,Shanxi Medical Universiy,Taiyuan 030000,China)

机构地区：[1]山西医科大学,山西太原030000 [2]山西医科大学第二医院骨科,山西太原030000

出　　处：《中国矫形外科杂志》2024年第8期733-737,共5页Orthopedic Journal of China

基　　金：山西省基础研究计划自然科学基金面上资助项目(编号:202203021221274)。

摘　　要：椎间盘退变(intervertebral disc degeneration, IVDD)是下腰痛(low back pain, LBP)的主要原因。IVDD过程伴随着细胞外基质代谢异常、促炎细胞因子释放增加和神经纤维及血管长入。同时已有研究表明,IVDD组织神经长入主要包括感觉神经和交感神经,神经在内层纤维环(annulus fibrosus, AF)和髓核(nucleus pulposus, NP)组织内的异位长入是LBP的主要原因。本文对IVDD组织内神经长入的进展进行概述,对神经纤维的调控和神经递质的作用进行讨论,希望通过针对神经长入的研究,有助于确定新的治疗方向。Intervertebral disc degeneration(IVDD) is the leading cause of low back pain(LBP), which is accompanied by abnormal metabolism of extracellular matrix, increased release of proinflammatory cytokines, and ingrowth of nerve fibers and blood vessels. At the same time, it has been shown that the innervation of IVDD tissue mainly includes sensory nerves and sympathetic nerves, and the ectopic ingrowth of the nerve into the inner annulus fibrosus(AF) and nucleus pulposus(NP) is the main cause of LBP. Here we give an overview of the progress of nerve ingrowth in IVDD, discuss the regulation of nerve fibers and the role of neurotransmitters. The research on nerve ingrowth may help to identify new therapeutic directions.

关 键 词：退变椎间盘 神经长入 下腰痛 治疗靶点 

分 类 号：R68[医药卫生—骨科学]