柳珊瑚来源真菌Penicillium chrysoygenum中的1个新的α吡喃酮发现  

A newα-Pyrone from the gorgonian-derived fungus Penicillium chrysogenum

作　　者：薛莹 周月 张雅慧 杨毅[4] 王长云[1,2] XUE Ying;ZHOU Yue;ZHANG Yahui;YANG Yi;WANG Changyun(Key Laboratory of Marine Drugs,Ministry of Education,School of Medicine and Pharmacy,Ocean University of China,Qingdao 266003,China;Laboratory for Marine Drugs and Bioproducts,Qingdao National Laboratory for Marine Science and Technology,Qingdao 266237,China;Shanxi Academy of Advanced Research and Innovation,Taiyuan 030032,China;College of Optoelectronics,Taiyuan University of Technology,Taiyuan 030024,China)

机构地区：[1]中国海洋大学海洋药物教育部重点实验室,医药学院,山东青岛266003 [2]青岛海洋科学与技术国家实验室海洋药物与生物制品功能实验室,山东青岛266237 [3]山西高等创新研究院,山西太原030032 [4]太原理工大学光电工程学院,山西太原030024

出　　处：《中国海洋药物》2024年第2期29-34,共6页Chinese Journal of Marine Drugs

基　　金：山东省自然科学基金项目(ZR2019ZD18)资助。

摘　　要：目的柳珊瑚来源真菌Penicillium chrysogenum(TA10-16)次级代谢产物及其生物活性研究。方法通过广泛的波谱数据,包括1D/2D NMR,HRESIMS和ECD谱从而确定化合物的结构。结果共分离获得7个聚酮化合物,包括1个新的α-Pyrone(1)和6个已知化合物(2~7),分别是pyrenocine E(2)、zanthopyranone(3)、emodin 8-O-methylether(4)、questinol(5)、(2S,3S)-1-(4-hydroxyphenyl)butane-2,3-diol(6)和4-hydroxybenzaldehyde(7)。化合物1和6对白色念珠菌表现出中等的抗真菌活性,最低抑菌浓度(MIC)为12.5μmol/L,而化合物7对白色念珠菌的MIC则为25.0μmol/L。结论化合物1的结构通过1D/2D NMR、HRESIMS和ECD等综合光谱数据进行了鉴定。同时,通过活性测试,化合物1和6具有潜在的抗真菌活性。Objective To study the secondary metabolites from the gorgonian-derived fungus Penicillium chrysogenum(TA10–16)and their biological activities.Methods The structure of the compounds were identified by comprehensive spectroscopic data,including 1D/2D NMR,HRESIMS and ECD.Results Seven polyketide compounds were isolated from a marine fungus Penicillium sp.,including a newα-Pyrone(1)and six known compounds(2–7),which were pyrenocine E(2),zanthopyranone(3),emodin 8-O-methylether(4),questinol(5),(2S,3S)-1-(4-hydroxyphenyl)butane-2,3-diol(6),and 4-hydroxybenzaldehyde(7).Compounds 1 and 6 showed moderate antifungal activity against Candida albicans with the same MIC values of 12.5μmol/L,while compound 7 showed weak activity against C.albicans with the MIC value of 25.0μmol/L.Conclusion The structure of compound 1 was elucidated by comprehensive spectroscopic data including 1D/2D NMR,HRESIMS and ECD.At the same time,compounds 1 and 6 had potential antifungal activity through activity test.

关 键 词：柳珊瑚来源 Penicillium chrysogenum 聚酮 ECD 抗真菌活性 

分 类 号：R931.77[医药卫生—生药学]