海洋产物的剂型研究进展  

Research progress on dosage forms of marine products

作　　者：唐宏广 蒋海云 王珍珍 刘彩萍 张建辉 陈雨欣 秦昆明 沈金阳 周越[2] TANG Hongguang;JIANG Haiyun;WANG Zhenzhen;LIU Caiping;ZHANG Jianhui;CHEN Yuxin;QIN Kunming;SHEN Jinyang;ZHOU Yue(School of Pharmacy,Jiangsu Ocean University,Lianyungang 222000,China;Department of Pharmacy,Lianyungang Hospital of Traditional Chinese Medicine,Lianyungang 222000,China)

机构地区：[1]江苏海洋大学药学院,江苏连云港222000 [2]连云港市中医院药学部,江苏连云港222000

出　　处：《中国海洋药物》2024年第2期85-94,共10页Chinese Journal of Marine Drugs

基　　金：国家自然科学基金项目(82374038);2023年全国中药特色技术传承人才培训项目;江苏省中药骨干人才高级研修项目资助。

摘　　要：海洋拥有十分丰富的生物资源,可以作为现代药用化合物来源的资源宝库。但值得注意的是,相当一部分海洋产物由于分子量大、脂溶性差、稳定性差、生物利用度低等缺点,被限制了在药物领域的开发利用。所以,将海洋产物制备成各种合适的剂型,赋予其新的理化性质,是在海洋药物研究过程中十分重要的程序。文章根据2010至2022年国内外海洋产物剂型的研究报道展开综述,把各类海洋产物按其化合物种类进行分类,综述各类海洋产物应用时存在的问题和剂型开发情况,以期为海洋产物的开发和新剂型的研究提供参考。The ocean is rich in biological resources and can serve as a treasure trove of resources for modern medicinal compounds.However,it is worth noting that a considerable number of marine products are limited in the development and utilization of drugs due to their large molecular weight,poor fat solubility,poor stability,and low bioavailability.Therefore,it is a very important procedure in the process of marine pharmaceutical research to prepare marine products into various suitable dosage forms and endow them with new physical and chemical properties.Based on the research reports on the dosage forms of marine products at home and abroad from 2010 to 2022,this paper classifies various marine products according to their compound types,and summarizes the problems existing in the application of various marine products and the development of dosage forms,in order to provide reference for the development of marine products and the research of new dosage forms.

关 键 词：海洋产物 剂型 生物利用度 稳定性 

分 类 号：R943[医药卫生—药剂学]