Hydrogen bond-bridged phosphorene flexible film for photodynamic inhibiting Staphylococcus aureus  

作　　者：Ziyu Wei Wenting Li Zhifang Liu Yongfa Zhu Huaqiang Cao 

机构地区：[1]Department of Chemistry,Engineering Research Center of Advanced Rare Earth Materials,Tsinghua University,Beijing 100084,China

出　　处：《Nano Research》2024年第6期5461-5468,共8页纳米研究（英文版）

基　　金：the National Natural Science Foundation of China(Nos.22171158 and 22136002);the Tribology Science Fund of the State Key Laboratory of Tribology(No.SKL TKF20B18).

摘　　要：Antibiotics are a widely used and effective treatment for bacterial infections.However,bacteria can gradually evolve during infection,leading to developing resistance to antibiotics,which renders previously effective treatments ineffective.Finding a useful and convenient manner to treat bacterial infections is a great challenge.Here,we report a flexible hydrogen-bond-bridged phosphorene film with photodynamic antibacterial properties and excellent mechanical properties,fabricated from electrochemical exfoliation of black phosphorus(BP).When illuminated under 700 nm light,the hydrogen bond-bridged phosphorene flexible film is capable of converting ground-state triplet oxygen(O_(2))into excited-state singlet oxygen(^(1)O_(2)),destroying the structure of the membrane of Staphylococcus aureus,and eventually leading to bacterial death,via breaking the C=C of unsaturated fatty acids within the bacterial cell membrane after the reaction between^(1)O_(2)and unsaturated fatty acids,thus realizing a highly efficient antibacterial approach,which is supported by gas chromatography-mass spectrometry(GC-MS)technique.This work establishes an effective phototherapy platform for treating bacterial traumatic infections.

关 键 词：hydrogen bond-bridged phosphorene flexible film photodynamic Staphylococcus aureus 

分 类 号：O62[理学—有机化学]