Recent advances in photoelectrochemistry-coupled dual-modal biosensors:From constructions to biosensing applications  

作　　者：Yuxiang Dong Weisa Wang Changqing Ye Yanlin Song 

机构地区：[1]School of Materials Science and Engineering,Suzhou University of Science and Technology,Suzhou 215009,China [2]Key Laboratory of Green Printing,Institute of Chemistry,Chinese Academy of Sciences,Beijing 100190,Chin

出　　处：《Nano Research》2024年第6期5512-5528,共17页纳米研究（英文版）

基　　金：the National Natural Science Foundation of China(Nos.52303153 and 51873145);the Basic science(Natural science)research project in universities of Jiangsu Province(No.23KJB150035);the Excellent Youth Foundation of Jiangsu Scientific Committee(No.BK20170065);the Qing Lan Project,the 5th 333 High-level Talents Training Project of Jiangsu Province(No.BRA2018340);the Six Talent Peaks Project in Jiangsu Province(No.XCL-79).

摘　　要：Precise and sensitive bioanalysis has been the major and urgent pursuit in pathologic diagnosis,food safety,environment monitoring,and drug evaluation.Photoelectrochemical(PEC)bioanalysis,as one of the most promising detection technologies,has rapidly expanded within the field of analysis.However,most of reported PEC analysis approaches still suffer from weak external anti-interference ability,high background,and the risk of false positive or negative errors due to their inherent single-signal readout.To overcome these shortcomings,new PEC-coupled dual-modal analysis approaches have been developed,where a dual-response signal can be derived through two completely different mechanisms and independent signal transduction pathways.This review introduces the basic principles of PEC biosensing and enumerates and classifies the substrate or probe selections,constructions,and applications of PEC-coupled dual-modal biosensors.Furthermore,the challenges and developmental prospects of PEC-coupled dual-mode sensing technologies are evaluated and discussed.We hope that this review will provide valuable insights into the latest advancements and practical applications of dual-mode PEC bioanalysis,which will be of great interest to those seeking to stay informed in this field.

关 键 词：photoelectrochemistry biosensor electrochemistry COLORIMETRY ELECTROCHEMILUMINESCENCE fluorescence dual-mode detection 

分 类 号：TP212.3[自动化与计算机技术—检测技术与自动化装置]