Reduction of photodynamic damage of blood vessels in the protected region by(–)-epigallocatechin gallate  

作　　者：Tianlong Chen Yi Shen Li Lin Huiyun Lin Xuejiao Song Defu Chen Buhong Li 

机构地区：[1]MOE Key Laboratory of OptoElectronic Science and Technology for Medicine,Fujian Provincial Key Laboratory of Photonics Technology,Fujian Normal University,Fuzhou 350117,P.R.China [2]Key Laboratory of Flexible Electronics and Institute of Advanced Materials,Nanjing Technology University,Nanjing 211800,P.R.China [3]School of Medical Technology,Beijing Institute of Technology,Beijing 100081,P.R.China

出　　处：《Journal of Innovative Optical Health Sciences》2024年第3期93-104,共12页创新光学健康科学杂志（英文）

基　　金：supported by the National Natural Science Foundation of China(Grant Nos.61935004,62227823 and 61805040);the Beijing Institute of Technology Research Fund Program for Young Scholars(XSQD-202123001).

摘　　要：Photodynamic therapy(PDT)has been increasingly used in the clinical treatment of neoplastic,inflammatory and infectious skin diseases.However,the generation of reactive oxygen species(ROS)may induce undesired side effects in normal tissue surrounding the treatment lesion,which is a big challenge for the clinical application of PDT.To date,(–)-Epigallocatechin gallate(EGCG)has been widely proposed as an antiangiogenic and antitumor agent for the protection of normal tissue from ROS-mediated oxidative damage.This study evaluates the regulation ability of EGCG for photodynamic damage of blood vessels during hematoporphyrin monomethyl ether(Hemoporfin)-mediated PDT.The quenching rate constants of EGCG for the triplet-state Hemoporfin and photosensitized 1O2 generation are determined to be 6.8×10^(8)M^(−1)S^(−1),respectively.The vasoconstriction of blood vessels in the protected region treated with EGCG hydrogel after PDT is lower than that of the control region treated with pure hydrogel,suggesting an efficiently reduced photodamage of Hemoporfin for blood vessels treated with EGCG.This study indicates that EGCG is an efficient quencher for triplet-state Hemoporfin and 1O2,and EGCG could be potentially used to reduce the undesired photodamage of normal tissue in clinical PDT.

关 键 词：(–)-Epigallocatechin gallate(EGCG) photodynamic therapy hemopor¯n singlet oxygen blood vessel vasoconstriction. 

分 类 号：R54[医药卫生—心血管疾病]