Cooperative activation of sodium channels for downgrading the energy efficiency in neuronal information processing  

作　　者：严浩然 颜家琦 俞连春 邵玉峰 Haoran Yan;Jiaqi Yan;Lianchun Yu;Yu-Feng Shao(School of Physical Science and Technology,Lanzhou Center for Theoretical Physics,Lanzhou University,Lanzhou 730000,China;Key Laboratory of Theoretical Physics of Gansu Province,and Key Laboratory of Quantum Theory and Applications of MoE,Lanzhou University,Lanzhou 730000,China;Department of Neuroscience,Anatomy,Histology,and Embryology,Key Laboratory of Preclinical Study for New Drugs of Gansu Province,School of Basic Medical Sciences,Lanzhou University,Lanzhou 730000,China)

机构地区：[1]School of Physical Science and Technology,Lanzhou Center for Theoretical Physics,Lanzhou University,Lanzhou 730000,China [2]Key Laboratory of Theoretical Physics of Gansu Province,and Key Laboratory of Quantum Theory and Applications of MoE,Lanzhou University,Lanzhou 730000,China [3]Department of Neuroscience,Anatomy,Histology,and Embryology,Key Laboratory of Preclinical Study for New Drugs of Gansu Province,School of Basic Medical Sciences,Lanzhou University,Lanzhou 730000,China

出　　处：《Chinese Physics B》2024年第5期758-763,共6页中国物理B（英文版）

基　　金：supported by the Fundamental Research Funds for the Central Universities(Grant No.lzujbky-2021-62);the Shanghai Municipal Science and Technology Major Project(Grant No.2018SHZDZX01);Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence(LCNBI)and ZJLab,and the National Natural Science Foundation of China(Grant No.12247101).

摘　　要：The Hodgkin–Huxley model assumes independent ion channel activation,although mutual interactions are common in biological systems.This raises the problem why neurons would favor independent over cooperative channel activation.In this study,we evaluate how cooperative activation of sodium channels affects the neuron’s information processing and energy consumption.Simulations of the stochastic Hodgkin–Huxley model with cooperative activation of sodium channels show that,while cooperative activation enhances neuronal information processing capacity,it greatly increases the neuron’s energy consumption.As a result,cooperative activation of sodium channel degrades the energy efficiency for neuronal information processing.This discovery improves our understanding of the design principles for neural systems,and may provide insights into future designs of the neuromorphic computing devices as well as systematic understanding of pathological mechanisms for neural diseases.

关 键 词：energy efficiency ion channel noise action potential generation neuronal dynamics 

分 类 号：TN911.7[电子电信—通信与信息系统] Q42[电子电信—信息与通信工程]