抗伪狂犬病病毒药物筛选研究进展  

Progress on Anti-PRV Drug Screening

作　　者：曹洁[1] 罗红彬[1] CAO Jie;LUO Hong-bin(Library of Northwest A&F University,Yangling,Shaanxi,712100,China)

机构地区：[1]西北农林科技大学图书馆,陕西杨凌712100

出　　处：《动物医学进展》2024年第7期107-113,共7页Progress In Veterinary Medicine

摘　　要：为揭示抗伪狂犬病病毒(PRV)药物筛选的研究趋势及发展方向,基于WOS、CNKI数据库及Citespace软件,从论文年度变化趋势、空间分布特点、关键词聚类、国际研究热点等方面对32年来PRV药物筛选领域的相关论文进行可视化分析。结果表明,1992-2023年,抗PRV药物筛选研究论文数量呈现先稳定后快速增长的态势,中国学者在该领域发表论文数量排名第一,河南农业大学是国内该领域的核心研究机构。国内研究主要集中在化学药物、以中草药为代表的天然生物提取物以及干扰素3个方面。国际上经历了从基础探索到CRISPR-Cas9利用的开发研究工具阶段,再到变种PRV的分子机制的深入研究3个阶段的发展历程。In order to reveal the research trend and development direction of anti-PRV drug screening,based on WOS,CNKI database and Citespace software,from the annual change trend,spatial distribution characteristics,keywords clustering,and international important issues of the 32 years of related papers were analyzed.The results showed that from 1992 to 2023,the number of research papers on anti-PRV drug screening presented a stable trend at first and then a rapid increase.China ranked first in the number of published papers in this field,Henan Agricultural University is the core research institution in this field in China.The domestic research mainly focuses on three aspects:chemical drugs,natural biological extracts represented by Chinese herbal medicine and interferon.The international community has gone through three stages,from basic exploration to the development of tools for CRISPR-Cas9 utilization to the in-depth study of the molecular mechanisms of variant PRV.

关 键 词：WOS数据库 CNKI数据库 CITESPACE 伪狂犬病病毒 抗病毒 

分 类 号：S859.2[农业科学—临床兽医学]