剪切波弹性成像检测尿道周围前列腺组织弹性模量与良性前列腺增生患者血清前列腺特异抗原的相关性研究  

Correlation study of the elastic modulus of shear wave elastography of periurethral prostatic tissue and serum PSA in patients with benign prostatic hyperplasia

作　　者：杨振兴[1] 魏灿[1] 席俊华[1] 齐伟[1] 张艳斌[1] Yang Zhenxing;Wei Can;Xi Junhua;Qi Wei;Zhang Yanbin(Department of Urology,The Second People’s Hospital of Hefei,Hefei 230001,China)

机构地区：[1]合肥市第二人民医院泌尿外科,合肥230001

出　　处：《中国医学装备》2024年第5期79-82,87,共5页China Medical Equipment

基　　金：国家自然科学基金(82004010)。

摘　　要：目的:分析尿道周围前列腺组织弹性模量与良性前列腺增生(BPH)患者血清前列腺特异抗原(PSA)的相关性。方法:采用便利抽样法收集2019年10月至2022年10月在合肥市第二人民医院接受治疗的200例BPH患者,所有患者均进行超声剪切波弹性成像与血清PSA检查,剪切波弹性成像测量尿道周围前列腺组织弹性模量取平均值,依据国际前列腺症状评分(IPSS)结果将其分为轻度组(96例)、中度组(59例)及重度组(45例),同时纳入本院前列腺检查人群中非前列腺病变的30名相关资料为健康对照组,分析比较患者尿道周围前列腺组织弹性模量与血清PSA的相关性。结果:统计学分析显示,各组受检者前列腺弹性模量值比较差异均有统计学意义(F=190.914,P<0.05)。与健康对照组相比,轻度组、中度组及重度组患者前列腺弹性模量值显著升高,差异有统计学意义(t=6.572、14.172、18.441,P<0.05);与轻度组相比,中度组、重度组患者前列腺弹性模量值显著升高(t=7.853、18.274,P<0.05);与中度组相比,重度组患者前列腺弹性模量值显著升高(t=11.371,P<0.05);不同程度的BPH患者间血清PSA差异均有统计学意义(F=126.143,P<0.05)。与健康对照组相比,轻度组、中度组及重度组患者血清PSA显著升高(t=10.694,14.368、13.804,P<0.001);与轻度组相比,中度组、重度组患者血清PSA显著升高(t=6.401、13.047,P<0.05);与中度组相比,重度组患者血清PSA显著升高(t=7.293,P<0.001);健康对照组血清PSA与尿道周围组织弹性模量无显著相关性(P>0.05)。轻度组、中度组及重度组患者血清PSA与尿道周围组织弹性模量均呈显著正相关(r=0.314、0.296、0.354,P<0.05)。结论:BPH患者血清PSA水平与尿道周围前列腺组织弹性模量值显著升高,二者存在正相关的关系。Objective:To analyze the correlation between elastic modulus of shear wave elastography of periurethral prostatic tissue and serum prostate-specific antigen(PSA)in patients with benign prostatic hyperplasia(BPH).Methods:A total of 200 BPH patients who received treatment in the Second People's Hospital of Hefei from October 2019 to October 2022 were collected by convenient sampling method,and all patients were subjected to ultrasound shear wave elastography and serum PSA examination,and the elastic modulus of periurethral prostate tissue was measured by shear wave elastography,and the mean of them was obtained.They were divided into mild group(96cases),moderate group(59 cases)and severe group(45 cases)according to the results of the International Prostate Symptom Score(IPSS).At the same time,the related information of 30 cases without prostatic lesions who were selected from the prostate examination population were included into healthy control groups.The correlation between the elastic modulus of periurethral prostatic tissue and serum PSA was analyzed and compared.Results:Statistical analysis showed that there was significant difference in the elastic modulus value of prostate among various groups(F=190.914,P<0.05).Compared with the healthy control group,the elastic modulus values of prostate of the mild,moderate and severe groups were significantly increased,and the differences were significant(t=6.572,14.172,18.441,P<0.05),respectively.Compared with the mild group,the elastic modulus values of prostate of the moderate and severe groups were significantly increased(t=7.853,18.274,P<0.05),respectively.Compared with the moderate group,the elasticity modulus value of prostate of the severe group significantly increased(t=11.371,P<0.05).There was significant difference in serum PSA among BPH patients with different degrees(F=126.143,P<0.05).Compared with the healthy control group,the serum PSA values of the mild,moderate and severe groups significantly increased(t=10.694,14.368,13.804,P<0.001),respectively.Compared

关 键 词：良性前列腺增生(BPH) 前列腺特异抗原(PSA) 剪切波弹性成像 相关性分析 

分 类 号：R697.3[医药卫生—泌尿科学]