下一代通用型临床科研专病数据库的建设理念框架思考  

Conceptual Framework of A Next-generation General-purpose Clinical Scientific Disease Database

作　　者：彭敏 陈倩茹 陈凯[1,3,4] PENG Min;CHEN Qianru;CHEN Kai(Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation,Sun Yat-sen Memorial Hospital,Sun Yat-sen University,Guangzhou 510120,China;Disease Registry Department,Sun Yat-sen Memorial Hospital,Sun Yat-sen University,Guangzhou 510120,China;Breast Tumor Center,Sun Yat-sen Memorial Hospital,Sun Yat-sen University,Guangzhou 510120,China;Artificial Intelligence Lab,Sun Yat-sen Memorial Hospital,Sun Yat-sen University,Guangzhou 510120,China)

机构地区：[1]中山大学孙逸仙纪念医院广东省恶性肿瘤表观遗传与基因调控重点实验室,广州510120 [2]中山大学孙逸仙纪念医院随访中心,广州510120 [3]中山大学孙逸仙纪念医院乳腺肿瘤中心,广州510120 [4]中山大学孙逸仙纪念医院人工智能研究室,广州510120

出　　处：《肿瘤防治研究》2024年第5期321-327,共7页Cancer Research on Prevention and Treatment

基　　金：国家自然科学基金(82271650);广东省发改委大数据工程实验室项目(4250022021);广州市科技计划项目(202102010221,20212200003);国家卫生健康委员会医院管理研究所课题(RXDBZ-2022-04);中山大学孙逸仙纪念医院逸仙管理项目(GL2307)。

摘　　要：基础医学、转化医学和临床医学在快速发展的人工智能技术与信息安全技术的赋能下,进入了一个全新的时代。在此过程中,相关的文本、基因、图像及视频等数据以惊人的速度增长。传统的专病数据库无法适应当下以及未来数据多模态化和数据来源多中心化的特点。建设下一代多模态多中心协作的、适合安全数据共享且符合伦理规范的临床科研专病数据库至关重要。本文阐述了具备通用性的构建下一代临床科研专病数据库的基本理念框架,强调建立多模态数据整合机制、以隐私计算为支撑的多中心协作体系、高智能化的软硬件实体以及一体化的运营管理模式,并介绍这一理念框架在中国乳腺癌创新联盟项目-乳腺癌立体化生命数据库建设中的应用。Empowered by the rapid development of artificial intelligence technology and information security technology,basic medicine,translational medicine,and clinical medicine have entered a new era.In this process,the relevant data such as text,genetics,images,and videos have increased at an astonishing rate.Traditional specialized disease databases cannot adapt to the multimodality of data and the multicentralization of data sources in the present/future.Therefore,establishing a next-generation multimodal and multicenter collaborative specialized disease database that is suitable for secure data sharing and ethical in clinical research is essential.This paper expounds the concept and basic framework of developing a next-generation clinical research disease database with universal use,emphasizing the establi-shment of a multimodal data integration mechanism,a multicenter collaborative system supported by privacy-preserving computing,highly intelligent software and hardware entities,and an integrated operational management mode.It also introduces the application of this conce-pt in the construction of a breast cancer three-dimensional life database,a proje-ct of China Breast Cancer Innovation Alliance.

关 键 词：专病数据 数据管理 临床科研数据库 数据库建设 乳腺癌 

分 类 号：R194[医药卫生—卫生事业管理]