阻塞性睡眠呼吸暂停的小脑MRI研究进展  

Progress in the evaluation of cerebellum in patients with obstructive sleep apnea by magnetic resonance imaging

作　　者：李利锋 刘玉婷 李海军[1,4] 彭德昌(审校)[1,4] LI Lifeng;LIU Yuting;LI Haijun;PENG Dechang(Department of Radiology,The First Affiliated Hospital,Jiangxi Medical College,Nanchang University,Nanchang 330006,China;Department of Radiology,The Affiliated Changsha Central Hospital,Hengyang Medical school,University of South China;Department of Ophthalmology,Hunan Children’s Hospital;PET Center,The First Affiliated Hospital,Jiangxi Medical College,Nanchang University)

机构地区：[1]南昌大学第一附属医院影像科,南昌330006 [2]南华大学附属长沙中心医院放射科 [3]湖南省儿童医院眼科 [4]南昌大学第一附属医院PET中心

出　　处：《国际医学放射学杂志》2024年第3期349-353,366,共6页International Journal of Medical Radiology

基　　金：国家自然科学基金(81860307);江西省临床医学研究中心组建任务(20223BCG74001);江西省2023年度研究生创新专项资金项目(YC2023-B077)。

摘　　要：阻塞性睡眠呼吸暂停(OSA)是一种高发的睡眠呼吸障碍性疾病,常导致认知功能损害而出现一系列神经系统改变。目前,多种MRI技术已用于揭示OSA病人小脑神经影像学的改变,包括基于体素的形态学分析(VBM)、动脉自旋标记(ASL)、静息态功能MRI(rs-fMRI)、扩散张量成像(DTI)及影像组学等,这些技术使得明确OSA病人小脑的神经生物学机制成为可能。综述多种MRI技术在OSA病人小脑结构和功能等方面的研究进展。Obstructive sleep apnea(OSA)is a highly prevalent sleep-disordered breathing disease that commonly leads to cognitive impairment and various neurological changes.Currently,multiple MRI techniques have been applied to reveal neuroimaging changes in the cerebellum in OSA patients.These techniques include voxel-based morphometry(VBM),arterial spin labeling(ASL),resting-state functional MRI(rs-fMRI),diffusion tensor imaging(DTI),and radiomics approaches.These methods have made it feasible to elucidate the neurobiological mechanisms of the cerebellum in OSA patients.This paper reviews the research progress on abnormalities in the structure and function of the cerebellum in OSA patients using various MRI modalities.

关 键 词：阻塞性睡眠呼吸暂停 小脑 静息态功能磁共振成像 认知功能 脑网络 

分 类 号：R445.2[医药卫生—影像医学与核医学] R747.9[医药卫生—诊断学]