不同血液净化方法对控制急性肾损伤的价值  

Value of Different Blood Purification Methods in the Control of Acute Kidney Injury

作　　者：李海东 LI Haidong(Department of Nephrology,Rudong Yangkou Hospital,Rudong,Jiangsu Province,226407 China)

机构地区：[1]江苏如东洋口医院肾内科,江苏如东226407

出　　处：《中外医疗》2024年第10期5-8,13,共5页China & Foreign Medical Treatment

摘　　要：目的分析血液净化治疗急性肾损伤的时机与方式。方法随机选取2020年1月—2023年1月江苏如东洋口医院收治的60例急性肾损伤患者作为研究对象,根据随机数表法分为观察组和对照组,各30例。均实施血液净化治疗,观察组接受持续性肾脏替代治疗,对照组接受间歇性肾脏替代治疗。比较两组临床疗效、肾功能、炎症因子水平、临床指标。结果观察组治疗总有效率为93.33%,高于对照组的73.33%,差异有统计学意义(χ^(2)=4.320,P<0.05)。治疗后,观察组血清肌酐、尿素氮、谷草转氨酶水平低于对照组,肾小球滤过率高于对照组,差异有统计学意义(P均<0.05)。治疗后,两组C反应蛋白、降钙素原、白细胞介素-6、肿瘤坏死因子-α水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P均<0.05)。观察组患者的急性生理学及慢性健康状况评分系统评分低于对照组,入住重症监护室时间短于对照组,差异有统计学意义(P均<0.05)。结论在明确诊断急性肾损伤后为其提供持续性肾脏替代治疗可改善患者肾功能及炎症因子水平,亦可缩短其入住重症监护室时间。Objective To analyze the time and method of blood purification in treating acute kidney injury.Methods A total of 60 patients with acute kidney injury admitted to Jiangsu Rudong Yangkou Hospital from January 2020 to January 2023 were randomly selected as the study objects and were divided into the the observation group and the control group by random number table method,with 30 cases in each group.All patients were treated with blood purification.The observation group received continuous renal replacement therapy,and the control group received intermittent renal replacement therapy.The clinical efficacy,renal function,inflammatory factor levels and clinical indexes of the two groups were compared.Results The clinical efficacy of the observation group was 93.33%,higher than 73.33%of the control group,the difference was statistically significant(χ^(2)=4.320,P<0.05).After treatment,the leves of serum creatinine,urea nitrogen and aspartate aminotransferase in the observation group were lower than those of the control group,glomerular filtration rate was higher than that of the control group,and the differences were statistically significant(all P<0.05).After treatment,the leves of C-reactive protein,procalcitonin,interleukin-6 and tumor necrosis factor-α in both groups were lower than those before teatment,and those of the observation group were lower than those of the control group,and the differences were statistically significant(all P<0.05).The scores of acute physiology and chronic health status scoring system in observation group was lower than that of the control group,and the time of stay in intensive care unit was shorter than that of the control group,and the differences were statistically significant(both P<0.05).Conclusion Providing continuous renal replacement therapy after a clear diagnosis of acute renal injury can improve the level of renal function and inflammatory factors,and shorten the time of hospitalization in intensive care unit.

关 键 词：急性肾损伤 诊断 早期 血液净化 肾功能 临床疗效 

分 类 号：R4[医药卫生—临床医学]