2020-2022年无锡市滨湖区孕妇孕中期唐氏筛查结果分析  

Analysis of Down's screening results during mid-term pregnancy in Binhu District,Wuxi City from 2020 to 2022

作　　者：王蕾 尤静洁 Wang Lei;You Jingjie(Department of Obstetrics and Gynecology,Wuxi Binhu District Maternal and Child Health and Family Planning Service Center,Wuxi 214000,China;Department of Gynecology,Tai Hu Rehabilitation Hospital of Jiangsu Province(Taihu Sanatoium of Jiangsu Province),Wuxi 214000,China)

机构地区：[1]无锡市滨湖区妇幼保健计划生育服务中心妇保科,江苏无锡214000 [2]江苏省太湖康复医院(江苏省太湖疗养院)妇科,江苏无锡214000

出　　处：《实用妇科内分泌电子杂志》2024年第7期7-9,共3页Electronic Journal of Practical Gynecological Endocrinology

摘　　要：目的 分析2020-2022年无锡市滨湖区孕妇孕中期唐氏筛查结果。方法 选取2020-2022年无锡市滨湖区6000例孕中期孕妇为观察对象,均进行唐氏筛查,包括检测其血清甲胎蛋白(AFP)和游离β绒毛膜促性腺激素(free-β-HCG)水平。在筛查软件中输入孕妇的年龄、体质量、孕周、种族、既往病史、血清标志物数值,最后计算出妊娠唐氏筛查风险率,高风险者必要时需配合羊膜腔穿刺抽取羊水细胞来分析染色体核型。结果 6000例孕妇中,唐氏综合征筛查高风险301例(5.02%);正常孕妇组的AFP高于唐氏综合征组、18-三体综合征组,free-β-HCG低于唐氏综合征组,高于18-三体综合征组,组间差异均有统计学意义(P<0.05)。正常孕妇组的AFP均高于唐氏综合征、18-三体综合征等小组的对应值,free-β-HCG低于唐氏综合征组,高于18-三体综合征组(P<0.05)。结论 唐氏综合征筛查作为一种初步的筛查方法,对无锡市滨湖区孕妇孕中期进行唐氏筛查,可以有效地对唐氏综合征、18-三体综合征等染色体疾病进行有效地筛查,可以预测异常胎儿结果和不良妊娠结局并进行科学处理,进而提高出生人口质量。Objective To analyze the results of mid pregnancy Down's syndrome screening in Binhu District,Wuxi City from 2020 to 2022.Methods 6000 mid pregnancy pregnant women in Binhu District,Wuxi City from 2020 to 2022 were selected as the observation subjects,all of whom underwent Down's screening,including testing their serum alpha fetoprotein(AFP)and free samplesβChorionic gonadotropin(free)-β-HCG level,then input the age,body mass,gestational week,race,past medical history,and serum biomarker values of the pregnant woman into the screening software,and finally calculate the pregnancy Down's screening risk rate.If necessary,high-risk individuals need to cooperate with amniocentesis to extract amniotic fluid cells and analyze chromosomal karyotypes.Results Among 6000 pregnant women,301(5.02%)were screened for Down's syndrome as high-risk.The AFP of the normal pregnant women group is higher than that of the Down's syndrome group and the trisomy 18 syndrome group,free-β-The HCG was lower in the Down's syndrome group and higher in the trisomy 18 syndrome group,with statistically significant differences between the groups(P<0.05).Conclusion As a preliminary screening method,Down's syndrome screening can effectively screen for chromosomal diseases such as Down's syndrome and trisomy 18.It can scientifically process the predicted results and improve the quality of the birth population.

关 键 词：唐氏筛查 血清甲胎蛋白 游离β绒毛膜促性腺激素 

分 类 号：R714.5[医药卫生—妇产科学]