血清β-HCG、雌二醇和孕酮联合检测在早期先兆流产诊断中的临床应用价值  

Clinical value of serum β-HCG,estradiol and progesterone combined detection in the diagnosis of early threatened abortion

作　　者：刘胜彬 古韵琳 王敏 Liu Shengbin;Gu Yunlin;Wang Min(Department of Clinical Laboratory,Meizhou Hospital of Traditional Chinese Medicine,Meizhou 514000,China)

机构地区：[1]梅州市中医医院医学检验科,广东梅州514000

出　　处：《实用妇科内分泌电子杂志》2024年第8期74-76,104,共4页Electronic Journal of Practical Gynecological Endocrinology

摘　　要：目的分析血清β-人绒毛膜促性腺激素(β-HCG)、雌二醇(E_(2))和孕酮(P)联合检测在早期先兆流产诊断中的临床应用价值。方法选取120例早孕患者,根据是否正常妊娠分为研究组(先兆流产)与对照组(正常妊娠),各60例。测定两组血清β-HCG、E_(2)和P水平,比较两组P、E_(2)、β-HCG水平的检出率及诊断价值、第5周、第7周血清P、E_(2)、β-HCG水平。结果研究组P、E_(2)、β-HCG水平检出率(63.33%、80.00%、43.33%)均高于对照组(0、8.33%、10.00%),差异有统计学意义(P<0.05)。β-HCG、E_(2)和P联合检测先兆流产的曲线面积(AUC)均大于β-HCG、E_(2)和P单独检测,差异有统计学意义(P<0.05)。研究组孕妇血清中β-HCG、E_(2)和P水平均低于对照组,差异有统计学意义(P<0.05)。研究组第5周、第7周血清中β-HCG、E_(2)和P水平均低于对照组,差异有统计学意义(P<0.05)。结论妊娠早期,血清β-HCG、E_(2)、P水平可反映胎儿状态和胎盘功能,提高早期先兆流产的诊断的准确率,对早孕患者进行监测具有重要的临床意义。Objective To analyze the clinical value of combined detection of serum β-Human chorionic gonadotropin(β-HCG),estradiol(E_(2))and progesterone(P)in the diagnosis of early threatened abortion.Methods 120 patients with early pregnancy were selected and divided into study group(threatened abortion)and control group(normal pregnancy),60 cases each.Serum levels of β-HCG,E,and P were measured in the two groups,and the detection rate and diagnostic value of P,E_(2) and β-HCG indexes in the two groups were compared,and the serum P,E_(2) and β-HCG indexes in the 5th and 7th weeks were compared.Results The detection rates of P,E_(2) and β-HCG indexes in study group(63.33%,80.00%,43.33%)were higher than those in control group(0,8.33%,10.00%),and the difference was statistically significant(P<0.05).The curve area(AUC)of β-HCG,E_(2) and P combined detection of threatened abortion was greater than that of β-HCG,E_(2) and P alone detection,and the difference was statistically significant(P<0.05).Serum β-HCG,E_(2) and P indexes in the study group were lower than those in the control group,and the difference was statistically significant(P<0.05).Serum β-HCG,E_(2) and P indexes in the study group were lower than those in the control group at week 5 and week 7,and the difference was statistically significant(P<0.05).Conclusion Serum β-HCG,E_(2) and P levels in early pregnancy can be used as indicators to reflect fetal status and placental function,which can improve the accuracy of diagnosis of early threatened abortion,and it is of great clinical significance to monitor early pregnant patients.

关 键 词：血清β-人绒毛膜促性腺激素 雌二醇 孕酮 早期先兆流产 应用价值 

分 类 号：R714.21[医药卫生—妇产科学]