综合护理在术前联合新辅助化疗治疗宫颈癌患者效果及对细胞因子的影响  

Effect of comprehensive care combined with neoadjuvant chemotherapy in cervical cancer patients and its effects oncytokines

作　　者：王冉 Wang Ran(Department of Gynecology and Oncology,Xuzhou Cancer Hospital,Xuzhou 221000,China)

机构地区：[1]徐州市肿瘤医院妇瘤科,江苏徐州221000

出　　处：《实用妇科内分泌电子杂志》2024年第8期113-115,共3页Electronic Journal of Practical Gynecological Endocrinology

摘　　要：目的分析综合护理在术前联合新辅助化疗治疗宫颈癌患者效果及对细胞因子的影响。方法选取80例行手术治疗且在术前均实施新辅助化疗治疗的宫颈癌患者,根据患者入院先后顺序分为参照组(实施常规护理)与观察组(实施综合护理),各40例。对比两组患者依从率、细胞因子及不良情绪评分。结果观察组总依从率为97.50%,较参照组的80.00%更高(P<0.05)。护理后观察组血清白介素-6(IL-6)、肿瘤坏死因子(TNF-α)水平均较参照组更低(P<0.05)。护理后观察组焦虑自评量表(SAS)、抑郁自评量表(SDS)评分为(38.67±2.31)分、(39.54±2.12)分,均分别较参照组的(43.96±2.66)分、(44.76±2.68)分更低(P<0.05)。结论对宫颈癌患者术前联合新辅助化疗治疗时进行综合护理干预效果良好,可以提高患者依从性,降低细胞因子水平,缓解其不良情绪,值得临床推广。Objective To analyze the effect of comprehensive nursing combined with neoadjuvant chemotherapy in the treatment of cervical cancer patients before surgery and its influence on cytokines.Methods 80 cervical cancer patients undergoing surgical treatment and receiving neoadjuvant chemotherapy before surgery were selected and divided into the reference group(receiving routine nursing)and the observation group(receiving comprehensive nursing)according to the order of admission,40 cases.The compliance rate,cytokines and adverse mood score were compared between the two groups.Results The total compliance rate of the observation group was 97.50%,which was higher than that of the reference group(80.00%,P<0.05).After nursing,the levels of serum interleukin-6(IL-6)and tumor necrosis factor(TNF-α)in observation group were lower than those in reference group(P<0.05).After nursing,the scores of the self-rating anxiety scale(SAS)and self-rating depression scale(SDS)in the observation group were(38.67±2.31)points and(39.54±2.12)points,which were lower than those of the reference group(43.96±2.66)points and(44.76±2.68)points respectively(P<0.05).Conclusion Comprehensive nursing intervention for cervical cancer patients combined with neoadjuvant chemotherapy before surgery has a good effect,can improve patient compliance,reduce cytokine levels,relieve their adverse emotions,and is worthy of clinical promotion.

关 键 词：新辅助化疗 宫颈癌 综合护理 细胞因子 

分 类 号：R473.73[医药卫生—护理学]