阴道前壁神经丛肽表达与阴部神经损伤的病理与临床研究  

Pathologic and clinical study on the expression of anterior vaginal plexus peptide and pudendal nerve injury

作　　者：凌惠媛 唐宁 杨梅[1] 黄玉葵[1] Ling Huiyuan;Tang Ning;Yang Mei;Huang Yukui(Department of Pathology,Nanning Maternal and Child Health Hospital,Nanning 530001,China)

机构地区：[1]南宁市妇幼保健院病理科,广西南宁530001

出　　处：《实用妇科内分泌电子杂志》2024年第9期8-10,共3页Electronic Journal of Practical Gynecological Endocrinology

基　　金：广西壮族自治区卫生健康委员会自筹经费科研课题(编号Z20211421)。

摘　　要：目的探讨阴道前壁神经丛肽表达(VIP)与阴部神经损伤的关系及阴部神经损伤引起盆底功能障碍性疾病的发病机制。方法收集40例盆底功能障碍性疾病患者设为研究组,40例其他妇科疾病患者设为对照组。采用半定量免疫组化法检测VIP在阴道前壁的表达;应用western-blot定量分析比较阴道前壁中VIP表达关系。结果盆腔脏器脱垂(POP)程度越重,固有层结构越紊乱、疏松,结缔组织可见断裂,小血管树胶较少;POP疾病越重,阴道前壁的血管、腺体、平滑肌减少。VIP表达从高到低依次为对照组、POP-QⅠ组、POP-QⅡ组、POP-QⅢ组、POP-QⅣ组。在POP-QⅢ组、POP-QⅣ组合并压力性尿失禁(SUI)、不合并SUI中,VIP几乎不表达(P>0.05)。结论阴道前壁VIP的表达与POP疾病程度具有负相关,盆腔脏器脱垂的多因素中绝经及合并SUI对POP的发生、发展较为重要。Objective To investigate the relationship between the expression of anterior vaginal plexus peptide(VIP)and pudendal nerve injury and the pathogenesis of pelvic floor dysfunction caused by pudendal nerve injury.Methods 40 patients with pelvic floor dysfunction were selected as the study group and 40 patients with other gynecological diseases were selected as the control group.The expression of viP in the anterior vaginal wall was detected by semi-quantitative immunohistochemistry.western blot quantitative analysis was used to compare the relationship of vIP expression in anterior vaginal wall.Results The more serious the degree of pelvic organ prolapse(Pop)is,the more disorganized and loose the lamina propria structure and the fracture of connective tissue can be seen.Small blood vessel gum less;The more severe the POP disease,the fewer blood vessels,glands,and smooth muscle in the front wall of the vagina.VIP expression from high to low was control group,POP-Q Ⅰ group,POP-QⅡ group,POP-QⅢ group and POP-QⅣ group.In POP-QⅡ group and POP-QⅣ group with SUI or without SUI,VIP was almost not expressed(P>0.05).Conclusion The expression of VIP in the anterior vaginal wall is negatively correlated with the degree of disease of POp.Among the multiple factors of pelvic organ prolapse,menopause and sUI are more important for the occurrence and development of PoP.

关 键 词：阴道前壁神经丛肽 阴部神经损伤 盆底功能障碍性疾病 发病机制 

分 类 号：R711.5[医药卫生—妇产科学]