人乳头瘤病毒检查、液基薄层细胞检测联合阴道镜检查在早期宫颈病变筛查中的意义  

Significance of human papillomavirus detection,liquid-based thin-layer cell detection and colposcopy examination in early cervical lesions screening

作　　者：顾永娟[1] Gu Yongjuan(Department of Obstetrics and Gynecology,Jianhu county People's Hospital,Yancheng 224700,China)

机构地区：[1]建湖县人民医院妇产科,江苏盐城224700

出　　处：《实用妇科内分泌电子杂志》2024年第11期83-85,93,共4页Electronic Journal of Practical Gynecological Endocrinology

摘　　要：目的探讨人乳头瘤病毒检查、液基薄层细胞检测联合阴道镜检查在早期宫颈病变筛查中的运用效果。方法选取110例疑似宫颈病变患者为研究对象,均接受人乳头瘤病毒检查、液基薄层细胞检测与阴道镜检查,以病理诊断结果为金标准,比较人乳头瘤病毒检查、液基薄层细胞检测及阴道镜检查与联合检查的阳性检出情况,以及单独检查与联合检查的诊断效能。结果病理诊断确诊低度鳞状上皮内病变24例、高度鳞状上皮内病变33例与宫颈癌12例;联合检查的阳性检出率为98.55%,高于人乳头瘤病毒检查、液基薄层细胞检测及阴道镜检查的84.06%、62.32%、86.96%(P<0.05);联合检查的准确率、敏感度、特异度、阳性预测值与阴性预测值高于人乳头瘤病毒检查、液基薄层细胞检测及阴道镜检查(P<0.05)。结论在早期宫颈病变诊断中运用人乳头瘤病毒检查、液基薄层细胞检测联合阴道镜检查,能够明显提高阳性检出率,且具有较高的诊断效能,值得推广。Objective To explore the application effect of human papillomavirus testing,liquid based thin-layer cell detection combined with colposcopy in early screening of cervical lesions.Methods 110 suspected cervical lesions patients were selected as the study subjects,all of whom underwent human papillomavirus testing,liquid based thin-layer cell testing,and colposcopy examination.The pathological diagnosis results were used as the gold standard to compare the positive detection of human papillomavirus testing,liquid based thin-layer cell testing,colposcopy examination,and combined examination,as well as the diagnostic efficacy of individual and combined examinations.Results Pathological diagnosis confirmed 24 cases of low-grade squamous intraepithelial lesions,33 cases of high grade squamous intraepithelial lesions,and 12 cases of cervical cancer;The positive detection rate of joint examination is 98.55%,which is higher than 84.06%,62.32%,and 86.96%of human papillomavirus test(P<0.05),liquid based thin-layer cell test,and colposcopy test;The accuracy,sensitivity,specificity,positive and negative predictive values of joint examination were higher than those of human papillomavirus examination,liquid based thin-layer cell detection,and colposcopy examination(P<0.05).Conclusion The use of human papillomavirus test,liquid based thin-layer cell detection combined with colposcopy in the early diagnosis of cervical lesions can significantly improve the positive detection rate and has high diagnostic efficacy,which is worth promoting.

关 键 词：早期宫颈病变 人乳头瘤病毒检查 液基薄层细胞检测 阴道镜检查 诊断价值 

分 类 号：R711.74[医药卫生—妇产科学]