左西孟旦应用于心脏手术的研究现状  

Research Status of Levosimendan in Cardiac Surgery

作　　者：李明前 杨朝坤[2] 李彦君 曹安 LI Ming-qian;YANG Chao-kun;LI Yan-jun;CAO An(School of Clinical Medical,Chengdu Medical College,Chengdu 610000,Sichaun,China;Department of Cardio-Thoracic Surgery,the Second People's Hospital of Yibin,Yibin 644000,Sichuan,China)

机构地区：[1]成都医学院临床医学院,四川成都610000 [2]宜宾市第二人民医院胸心外科,四川宜宾644000

出　　处：《医学信息》2024年第11期184-188,共5页Journal of Medical Information

摘　　要：左西孟旦是新一代的正性肌力药物,它避免了传统强心药物增加心肌耗氧量的风险,具有运用于心脏外科手术的巨大潜力。只有部分临床研究证实左西孟旦运用于心脏手术在血流动力学、血液检测指标、住院时间等方面有益处,而在心衰发生率、死亡率等方面的优势并未超越传统正性肌力药物。本文就左西孟旦的作用机理及在心脏外科围手术期不同时间段使用的研究情况进行综述,为其临床应用提供参考。Levosimendan is a new generation of positive inotropic drug that has great potential for use in cardiac surgery,as it avoids the risk of increased myocardial oxygen consumption associated with traditional cardiac drugs.Only some clinical studies have confirmed the benefits of levosimendan in cardiac surgery in terms of hemodynamics,blood test indexes,and hospital stay,while its advantages in terms of heart failure incidence and mortality have not surpassed those of traditional positive inotropic drugs.This article reviews the mechanism of action of levosimendan and its use in different time periods in the perioperative period of cardiac surgery to provide a reference for its clinical application.

关 键 词：左西孟旦 作用机理 心脏手术 

分 类 号：R654.2[医药卫生—外科学]