江门地区女性HPV感染、宫颈病变与阴道微生态的相关性分析  

Correlation Analysis of Female Genital HPV Infection,Cervical Lesions and Vaginal Microecology

作　　者：林悦欢[1] 詹雪梅[1] 胡杏军[1] 王嵘[1] Lin Yuehuan;Zhan Xuemei;Hu Xingjun;Wang Rong(Jiangmen Central Hospital,Guangdong Jiangmen 529030)

机构地区：[1]江门市中心医院,广东江门529030

出　　处：《哈尔滨医药》2024年第2期28-30,共3页Harbin Medical Journal

基　　金：江门市科技计划项目(2020020301130003139)。

摘　　要：目的探讨广东省江门地区女性生殖道HPV感染、宫颈病变与阴道微生态的相关性,为本地区宫颈病变的防治提供新的依据。方法回顾性分析8067例TCT和HPV检测的女性资料,分析江门地区女性生殖道HPV感染、宫颈病变与阴道微生态的相关性。结果纳入研究的8067例女性,阴道微生态乳酸杆菌少量/无3267例,占40.50%,清洁度异常1323例,占16.40%,细菌性阴道病2237例,占27.73%,念珠菌感染1579例,占19.70%,滴虫感染223例,占2.76%,从相关检验结果显示:女性HPV感染、宫颈病变与阴道微生态(乳酸杆菌、清洁度、细菌性阴道病、滴虫感染)密切相关(P<0.05),但与阴道念珠菌感染差异无统计学意义(P>0.05);结论江门地区女性阴道微生态与HPV感染、宫颈病变密切相关,阴道微生态失衡,优势菌减少,菌群失衡,病原菌侵入,清洁度异常,增加HPV感染和宫颈病变发生的风险,因此,HPV感染、宫颈病变的预防可从改善女性阴道微生态入手。Objective To explore and analyze the correlation between female genital HPV infection,cervical lesions and vaginal microecology,and to provide a new basis for the prevention and treatment of cervical lesions.Methods Data of 8067 female patients with TCT and HPV testing were retrospectively analyzed,and the correlation between genital HPV infection,cervical lesions and vaginal microecology in women in Jiangmen area was analyzed.Results Among the 8067 women included in the study,3267 cases had little or no vaginal microecological lactobacillus,accounting for 40.50%,1323 cases had abnormal cleanliness,accounting for 16.40%,2237 cases had bacterial vaginosis,accounting for 27.73%,1579 cases had candida infection,accounting for 19.70%,223 cases had trichomonas infection,accounting for 2.76%.Rank correlation test showed that HPV infection and cervical lesions were closely correlated with vaginal microecology(Lactobacillus,cleanliness,bacterial vaginosis,trichomonas infection)(P<0.05),but had no significant correlation with vaginal candida infection(P>0.05).Conclusion Female vaginal microecology is closely related to HPV infection and cervical lesions.Imbalance of vaginal microecology,reduction of dominant bacteria,imbalance of bacterial flora,pathogen invasion and abnormal cleanliness increase the risk of HPV infection and cervical lesions.Therefore,prevention of HPV infection and cervical lesions can be started from improving female vaginal microecology.

关 键 词：HPV感染 宫颈病变 阴道微生态 相关性 

分 类 号：R711.32[医药卫生—妇产科学]