(9H-氧杂蒽-9-羰基)甘氨酸乙酯的电化学合成研究  

Electrochemical Synthesis of Ethyl (9H-xanthene-9-carbonyl)glycinate

作　　者：张佳慧 胡洋洋 孙靖文 刘慧莹 陶轶 刘磊[1] ZHANG Jiahui;HU Yangyang;SUN Jingwen;LIU Huiying;TAO Yi;LIU Lei(Qiqihar Medical University,Qiqihar 161006,China;Third Affiliated Hospital of Qiqihar Medical University,Qiqihar 161000,China)

机构地区：[1]齐齐哈尔医学院药学院,黑龙江齐齐哈尔161006 [2]齐齐哈尔医学院附属第三医院,黑龙江齐齐哈尔161000

出　　处：《化工管理》2024年第14期138-142,共5页Chemical Engineering Management

基　　金：齐齐哈尔市科技计划联合引导项目(LSFGG—2023025)。

摘　　要：甘氨酸乙酯类结构作为许多生物活性化合物的关键结构基序和多用途的构建模块,一直是研究的热点。利用绿色可持续的电力作为输出能源,以氧杂蒽和异氰基乙酸乙酯为原料,通过电催化酰化反应来合成(9H-氧杂蒽-9-羰基)甘氨酸乙酯,利用核磁共振氢谱、核磁共振碳谱和质谱对其结构进行表征,并考察了在不同电极、电解质、电流、溶剂、温度条件下对其产率的影响。该方法收率较高,产物的原材料易获取,为合成甘氨酸乙酯类结构提供了一种独特的方案。The glycine ethyl ester structure,serving as a key structural motif and multi-purpose building block for many bioactive compounds,has been the focus of research.In this study,the target product was synthesized through electrocatalytic acylation of oxanthracene and ethyl isocyanoacetate using green and sustainable electricity as the energy source.The structure of the product was characterized using 1HNMR,13CNMR,and HRMS.The effects of different electrodes,electrolytes,currents,solvents,and temperatures on the yield were investigated.This method offers a distinctive approach for synthesizing glycine ethyl ester structures with a high yield and easy access to raw materials.

关 键 词：电化学合成 氧杂蒽 异氰基乙酸乙酯 甘氨酸乙酯 

分 类 号：O622[理学—有机化学]