双膦酸盐类药物用于钙化防御治疗的文献分析  

Literature Review of Using Bisphosphonates in the Treatment of Calciphylaxis

作　　者：梁春苏 王少红 张逸舟 刘鑫[1] 牛子冉 史亦丽[1] 张波[1,2] LIANG Chunsu;WANG Shaohong;ZHANG Yizhou;LIU Xin;NIU Ziran;SHI Yili;ZHANG Bo(Department of Pharmacy,National Rare Disease Medical Quality Control Center,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing 100730,China;State Key Laboratory of Complex Severe and Rare Diseases,National Rare Disease Medical Quality Control Center,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing 100730,China)

机构地区：[1]中国医学科学院北京协和医院药剂科,北京100730 [2]中国医学科学院北京协和医院疑难重症及罕见病全国重点实验室、国家罕见病医疗质量控制中心,北京100730

出　　处：《罕见病研究》2024年第2期214-220,共7页Journal of Rare Diseases

基　　金：国家自然科学基金(82304456);中央高水平医院临床科研业务费(2022-PUMCH-B-059)。

摘　　要：目的分析双膦酸盐类药物用于钙化防御患者治疗的有效性和安全性。方法检索PubMed、Embase、中国知网及万方数据库,收集报道双膦酸盐用于钙化防御的病例报告,提取患者相关信息进行统计分析。结果纳入文献共18篇病例报告,患者20例,结果显示13例患者(65.0%)采用帕米膦酸盐治疗,4例患者(20.0%)采用依替膦酸盐,2例患者(10.0%)采用阿仑膦酸盐,1例患者(5.0%)采用唑来膦酸。13例患者(65.0%)完全康复,康复时间为0.5~9个月。大部分患者双膦酸盐类药物的耐受性较好(90.0%),1例不耐受帕米膦酸盐的患者在调整给药频次后康复,1例依替膦酸盐高给药剂量患者在停用后指标恢复正常。结论双膦酸盐类药物作为一种骨吸收的抑制剂,兼具有效性和安全性,有望用于钙化防御患者的治疗。Objective To analyze the effectiveness and safety of bisphosphonates in the treatment of patients with calcification defense.Methods PubMed,Embase databases,CNKI and Wanfang were searched to collect the case reports and clinical studies of bisphosphonates for calcification defense.Then,the relevant information of patients was extracted for statistical analysis.Results A total of 18 case reports were selected involving 20 patients.Thirteen patients(65.0%)were treated with pamidronate,four(20.0%)were treated with etidronate,two(10.0%)were treated with alendronate,and one(5.0%)was treated with zoledronic acid.Thirteen patients(65.0%)recovered completely,the recovery time of whom ranged from half month to nine months.The tolerance of bisphosphonates in most patients(90.0%)was good,while one patient who did not tolerate pamidronate recovered after the frequency of administration was adjusted and one patient with high dosage of etidronate returned to normal after the discontinuation of the usage.Conclusions Bisphosphonates,an inhibitor of bone resorption,is effective and safe in the treatment of patients with calcification defense.

关 键 词：钙化防御 双膦酸盐 帕米膦酸盐 阿仑膦酸盐 唑来膦酸 

分 类 号：R686[医药卫生—骨科学]